Characterization of an interspersed repetitive DNA element in the genome of Trypanosoma cruzi

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dc.contributor.authorAraya, J.
dc.contributor.authorCano, M. I.
dc.contributor.authorGomes, HBM
dc.contributor.authorNovak, E. M.
dc.contributor.authorRequena, J. M.
dc.contributor.authorAlonso, C.
dc.contributor.authorLevin, M. J.
dc.contributor.authorGuevara, P.
dc.contributor.authorRamirez, J. L.
dc.contributor.authorDa Silveira, J. F.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Antofagasta
dc.contributor.institutionUAM
dc.contributor.institutionIngebi
dc.contributor.institutionUCV
dc.date.accessioned2016-01-24T12:30:30Z
dc.date.available2016-01-24T12:30:30Z
dc.date.issued1997-12-01
dc.description.abstractWe report the molecular characterization of a middle repetitive DNA sequence, named C6, isolated from the Trypanosoma cruzi genome. C6 appears to be a composite repeated element since 3 subregions may be defined within it on the basis of sequence similarities with other T. cruzi genomic sequences. Sequences homologous to C6 are interspersed in the genome and can be mapped out on most chromosomal bands of different T. cruzi. strains. the copy number of the C6 element is about 1000 per haploid genome. Given the species specificity and different genomic distribution of C6 homologous sequences among the T. cruzi strains the C6 element could be a useful probe for diagnosis and typing of parasites. C6 is a polymorphic marker with potential as a tool for physical mapping of the T. cruzi genome.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Antofagasta, Unidad Parasitol, Antofagasta, Chile
dc.description.affiliationUAM, CSIC, Ctr Biol Mol Severo Ochoa, Madrid 28049, Spain
dc.description.affiliationIngebi, RA-1428 Buenos Aires, DF, Argentina
dc.description.affiliationUCV, Ctr Biol Celular, Caracas, Venezuela
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent563-570
dc.identifierhttp://dx.doi.org/10.1017/S0031182097001674
dc.identifier.citationParasitology. New York: Cambridge Univ Press, v. 115, p. 563-570, 1997.
dc.identifier.doi10.1017/S0031182097001674
dc.identifier.issn0031-1820
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25824
dc.identifier.wosWOS:000071657500001
dc.language.isoeng
dc.publisherCambridge Univ Press
dc.relation.ispartofParasitology
dc.rightsAcesso restrito
dc.rights.licensehttp://journals.cambridge.org/action/displaySpecialPage?pageId=4676
dc.subjectTrypanosoma cruzi repetitive DNAen
dc.subjectsequence analysisen
dc.subjectgenomic distributionen
dc.subjectpolymorphic markeren
dc.subjectdiagnostic toolen
dc.titleCharacterization of an interspersed repetitive DNA element in the genome of Trypanosoma cruzien
dc.typeArtigo
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