Efeitos do canabidiol na recuperação muscular: revisão narrativa da literatura
Arquivos
Data
2023-12-21
Autores
Almeida, João Pedro Fernandes Santiago 
Orientadores
Santos, Ronaldo Vagner Thomatieli dos
Tipo
Trabalho de conclusão de curso
Título da Revista
ISSN da Revista
Título de Volume
Resumo
A recuperação muscular pós-exercício é um tópico de amplo interesse entre indivíduos praticantes de exercício físico, por conta das manifestações físicas, fisiológicas e cognitivas do acúmulo de fadiga. A atenção da comunidade científica nos últimos anos se voltou à busca por novos métodos capazes de otimizar o tempo de recuperação. Estudos de corte transversal mostram uma grande prevalência no uso de anti-inflamatórios não esteróides (AINEs) por praticantes de exercício físico e atletas, visando principalmente o seu efeito analgésico nos sinais clínicos da dor muscular de início tardio (DMIT), mas também a resolução completa do processo de recuperação muscular. Nesse âmbito, o canabidiol (CBD) tem demonstrado ser uma alternativa mais segura aos AINEs, com poucos efeitos colaterais relacionados ao seu uso. O mecanismo de ação do CBD nos processos relativos à recuperação muscular é complexo, e ocorre pelas suas interações com uma variedade de receptores do sistema endocanabinóide, com o potencial de modular diversas funções relacionadas a esses processos. Entre essas funções, o presente estudo destacou o dano muscular induzido por exercício, a resposta inflamatória, o DMIT e o sono como componentes fundamentais para uma recuperação otimizada. Para entender as possíveis aplicações da administração de CBD em um contexto de recuperação muscular, realizou-se uma revisão narrativa da literatura disponível na base de dados Pubmed utilizando, de forma combinada, os descritores "canabidiol", "exercício físico", "dano muscular induzido por exercício", "inflamação" ou "sono" como base, entre os anos 2010 a 2023. As evidências disponíveis até o momento parecem promissoras, mas não permitem afirmar que o uso de CBD seja eficaz na melhora de parâmetros da recuperação muscular. Poucos ensaios clínicos direcionaram seu objeto de pesquisa a essa temática, e a literatura se apropria de estudos não relacionados ao exercício físico para criar hipóteses. Conclui-se que o nível de evidência dos efeitos do CBD na recuperação muscular ainda é considerado muito baixo, com a pouca quantidade de ensaios clínicos mostrando algum efeito direto entre as variáveis de estudo. A crescente prevalência do uso de CBD entre praticantes de exercício físico está embasado em evidências empíricas, percepções subjetivas de resultados positivos, e estudos in vitro.
Post-exercise muscle recovery is a topic of broad interest between physically active individuals, because of their physical, physiological, and cognitive manifestations of fatigue accumulation. Attention of the scientific community in recent years turned to the search of novel methods looking to optimize recovery time. Cross-sectional studies showed a high prevalence on use of non-steroidal anti-inflammatory drugs (NSAIDs) by physically active individuals and athletes, mainly aiming their analgesic effects on clinical signs of delayed-onset muscle soreness (DOMS), but also the full resolution of muscle recovery process. In this scope, cannabidiol (CBD) has demonstrated to be a safer alternative to NSAIDs, with small side effects related to its use. CBD mechanism of action on processes related to muscle recovery is complex, and occurs by their interaction with a variety of cannabinoid receptors on the endocannabinoid system, potentially modulating various functions on this processes. Among these functions, the present study highlights the exercise-induced muscle damage (EIMD), inflammatory response, DOMS and sleep as primary components of optimal recovery. To understand the possible applications of CBD use in a muscle recovery context, a narrative review was carried out in the available literature on database Pubmed using, in a combined way, the descriptors "cannabidiol", "physical exercise", "exercise-induced muscle damage", "inflammation", or "sleep" as a basis, between the years 2010 and 2023. The available evidence to this moment looks promising, but does not allow to claim that CBD use is effective in improving muscle recovery parameters. Few clinical trials have directed their research object to this theme, and literature appropriate of studies non-targeted to physical exercise to raise hypotheses. It is concluded that the level of evidence on CBD effects at muscle recovery remains very low, with little quantity of clinical trials showing some direct effects between the study variables. The growing prevalence of CBD use between physically active individuals is based on empirical evidence, subjective perception of positive outcomes, and in vitro studies.
Post-exercise muscle recovery is a topic of broad interest between physically active individuals, because of their physical, physiological, and cognitive manifestations of fatigue accumulation. Attention of the scientific community in recent years turned to the search of novel methods looking to optimize recovery time. Cross-sectional studies showed a high prevalence on use of non-steroidal anti-inflammatory drugs (NSAIDs) by physically active individuals and athletes, mainly aiming their analgesic effects on clinical signs of delayed-onset muscle soreness (DOMS), but also the full resolution of muscle recovery process. In this scope, cannabidiol (CBD) has demonstrated to be a safer alternative to NSAIDs, with small side effects related to its use. CBD mechanism of action on processes related to muscle recovery is complex, and occurs by their interaction with a variety of cannabinoid receptors on the endocannabinoid system, potentially modulating various functions on this processes. Among these functions, the present study highlights the exercise-induced muscle damage (EIMD), inflammatory response, DOMS and sleep as primary components of optimal recovery. To understand the possible applications of CBD use in a muscle recovery context, a narrative review was carried out in the available literature on database Pubmed using, in a combined way, the descriptors "cannabidiol", "physical exercise", "exercise-induced muscle damage", "inflammation", or "sleep" as a basis, between the years 2010 and 2023. The available evidence to this moment looks promising, but does not allow to claim that CBD use is effective in improving muscle recovery parameters. Few clinical trials have directed their research object to this theme, and literature appropriate of studies non-targeted to physical exercise to raise hypotheses. It is concluded that the level of evidence on CBD effects at muscle recovery remains very low, with little quantity of clinical trials showing some direct effects between the study variables. The growing prevalence of CBD use between physically active individuals is based on empirical evidence, subjective perception of positive outcomes, and in vitro studies.
Descrição
Citação
ALMEIDA, João Pedro Fernandes Santiago. Efeitos do canabidiol na recuperação muscular: revisão narrativa da literatura. 2023. 36 f. Trabalho de conclusão de curso (Graduação em Educação Física) - Universidade Federal de São Paulo, Instituto de Saúde e Sociedade, Santos, 2023.