Linear and nonlinear analysis of heart rate variability in healthy subjects and after acute myocardial infarction in patients

Linear and nonlinear analysis of heart rate variability in healthy subjects and after acute myocardial infarction in patients

Author Kunz, V.c. Google Scholar
Borges, E.n. Google Scholar
Coelho, Regina Célia Autor UNIFESP Google Scholar
Gubolino, L.a. Google Scholar
Martins, L.e.b. Google Scholar
Silva, E. Google Scholar
Institution Universidade Federal de São Carlos Departamento de Fisioterapia Núcleo de Pesquisa em Exercício Físico
Universidade Metodista de Piracicaba Faculdade de Ciências da Saúde
Universidade Federal de São Paulo (UNIFESP)
Unidade Coronariana do Hospital dos Fornecedores de Cana de Piracicaba
Universidade Estadual de Campinas (UNICAMP)
Abstract The objectives of this study were to evaluate and compare the use of linear and nonlinear methods for analysis of heart rate variability (HRV) in healthy subjects and in patients after acute myocardial infarction (AMI). Heart rate (HR) was recorded for 15 min in the supine position in 10 patients with AMI taking β-blockers (aged 57 ± 9 years) and in 11 healthy subjects (aged 53 ± 4 years). HRV was analyzed in the time domain (RMSSD and RMSM), the frequency domain using low- and high-frequency bands in normalized units (nu; LFnu and HFnu) and the LF/HF ratio and approximate entropy (ApEn) were determined. There was a correlation (P < 0.05) of RMSSD, RMSM, LFnu, HFnu, and the LF/HF ratio index with the ApEn of the AMI group on the 2nd (r = 0.87, 0.65, 0.72, 0.72, and 0.64) and 7th day (r = 0.88, 0.70, 0.69, 0.69, and 0.87) and of the healthy group (r = 0.63, 0.71, 0.63, 0.63, and 0.74), respectively. The median HRV indexes of the AMI group on the 2nd and 7th day differed from the healthy group (P < 0.05): RMSSD = 10.37, 19.95, 24.81; RMSM = 23.47, 31.96, 43.79; LFnu = 0.79, 0.79, 0.62; HFnu = 0.20, 0.20, 0.37; LF/HF ratio = 3.87, 3.94, 1.65; ApEn = 1.01, 1.24, 1.31, respectively. There was agreement between the methods, suggesting that these have the same power to evaluate autonomic modulation of HR in both AMI patients and healthy subjects. AMI contributed to a reduction in cardiac signal irregularity, higher sympathetic modulation and lower vagal modulation.
Keywords Myocardial infarction
Heart rate variability
Autonomic nervous system
Spectral analysis
Nonlinear dynamics
Language English
Date 2012-05-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 45, n. 5, p. 450-458, 2012.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 450-458
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000303940200011
SciELO ID S0100-879X2012000500011 (statistics in SciELO)

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