Suplementação de vitamina D na função muscular em idosos: uma revisão sistemática de ensaios clínicos randomizados
Data
2021-11-18
Autores
Maesaka, Mirella [UNIFESP]
Orientadores
Lambertucci, Rafael Herling [UNIFESP]
Tipo
Dissertação de mestrado
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Objetivo: a avaliação funcional é muito importante entre os idosos, visando evitar a dependência e quedas. A vitamina D tem sido muito estudada por seus benefícios músculo-esqueléticos. Segundo a Sociedade Brasileira de Endocrinologia níveis de vitamina D acima de 30 ng/mL ou 75 nmol/L são considerados suficientes. Esse estudo foi conduzido para resumir dados importantes e avaliar o efeito da suplementação de vitamina D na função muscular entre indivíduos acima de 60 anos. Métodos: Foi realizada pesquisa até 10 de fevereiro de 2021 no Medline, Cochrane, Clinical Trials, Embase, Open Grey, WHO, Lilacs. Foram avaliados como desfechos os testes Time Up and Go (TUG) e Short Physical Performance Battery (SPPB). Resultados: foram identificados 1.138 estudos inicialmente, dos quais foram escolhidos 17 baseados nos critérios de elegibilidade, com 2.984 pacientes. Houve melhora na função muscular com doses de 800 a 2.000 UI diárias, com ou sem cálcio, e com uma dose mensal de 60.000 UI sem cálcio. Os níveis de vitamina D basal no sangue foram abaixo de 28 ng/mL nos 17 estudos da nossa revisão. Conclusão: a vitamina D suplementada entre idosos teve um modesto efeito positivo na função muscular em estudos clínicos com status séricos abaixo de 21 ng/mL.
Objective: Functional assessment is very important among the elderly, aiming to avoid dependence and falls. Vitamin D has been widely studied for its musculoskeletal benefits. According to the Brazilian Society of Endocrinology, vitamin D levels above 30 ng/mL or 75 nmol/L are considered sufficient. This study was conducted to summarize important data and to evaluate the effect of vitamin D supplementation on muscle function among individuals over 60 years of age. Methods: A search was performed until February 10, 2021 in Medline, Cochrane, Clinical Trials, Embase, Open Grey, WHO, Lilacs. The Time Up and Go (TUG) and Short Physical Performance Battery (SPPB) tests were evaluated as endpoints. Results: 1,138 studies were initially identified, from which 17 were chosen based on eligibility criteria, with 2,984 patients. There was improvement in muscle function with doses of 800 to 2,000 IU daily, with or without calcium, and with a monthly dose of 60,000 IU without calcium. Basal blood vitamin D levels were below 28 ng/mL in all 17 studies in our review. Conclusion: supplemented vitamin D among the elderly had a modest positive effect on muscle function in clinical studies with serum status below 21 ng/mL.
Objective: Functional assessment is very important among the elderly, aiming to avoid dependence and falls. Vitamin D has been widely studied for its musculoskeletal benefits. According to the Brazilian Society of Endocrinology, vitamin D levels above 30 ng/mL or 75 nmol/L are considered sufficient. This study was conducted to summarize important data and to evaluate the effect of vitamin D supplementation on muscle function among individuals over 60 years of age. Methods: A search was performed until February 10, 2021 in Medline, Cochrane, Clinical Trials, Embase, Open Grey, WHO, Lilacs. The Time Up and Go (TUG) and Short Physical Performance Battery (SPPB) tests were evaluated as endpoints. Results: 1,138 studies were initially identified, from which 17 were chosen based on eligibility criteria, with 2,984 patients. There was improvement in muscle function with doses of 800 to 2,000 IU daily, with or without calcium, and with a monthly dose of 60,000 IU without calcium. Basal blood vitamin D levels were below 28 ng/mL in all 17 studies in our review. Conclusion: supplemented vitamin D among the elderly had a modest positive effect on muscle function in clinical studies with serum status below 21 ng/mL.
Descrição
Citação
MAESAKA, Mirella. Suplementação de vitamina D na função muscular em idosos: uma revisão sistemática de ensaios clínicos randomizados. 2021. 48 f. Dissertação (Mestrado Interdisciplinar em Ciências da Saúde) - Instituto de Saúde e Sociedade, Universidade Federal de São Paulo, Santos, 2021.