Potencial de metabólitos secundários fúngicos na prevenção e tratamento de doenças neurodegenerativas
Data
2021-12-15
Autores
Berardinelli, Marcos Vinicius Lourenço [UNIFESP]
Orientadores
Medeiros, Lívia Soman de [UNIFESP]
Tipo
Trabalho de conclusão de curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Estudos recentes alertam sobre o agravamento nos casos de doenças neurodegenerativas com o aumento da expectativa de vida da população mundial. Devido ao aumento de distúrbios neurológicos como Alzheimer, Parkinson e Esclerose Lateral Amiotrófica, a busca por novos tratamentos mostra-se cada vez mais importante. Neste cenário, este trabalho traz à luz o potencial de metabólitos secundários de origem fúngica, em especial do filo Ascomycota, como candidatos na busca de agentes terapêuticos para doenças neurodegenerativas e também com atuação no espectro da neuroproteção. Por meio de pesquisa bibliográfica sobre o tema, no período de 2010 a 2020, o trabalho discutirá e analisará os produtos naturais de origem fúngica relatados na literatura, mediante a seleção de importantes parâmetros como ação biológica, estrutura química e classificação biossintética. Contudo, a curadoria de dados deste trabalho poderá auxiliar em futuras investigações quanto a implementação de triagens químicas e biológicas mais focadas, com relação a bioprospecção de alvos mais promissores, visando o desenvolvimento de agentes terapêuticos que possam ser empregados no combate às doenças relacionadas ao sistema nervoso humano. Cerca de 115 artigos foram selecionados e, através de processo de triagem e anotação, observou-se um maior número de compostos com mecanismo de ação anti-inflamatório e antioxidante. Resultados mostram que a classe dos policetideos representam 44% de todos os compostos revisados, sendo a classe biossintética de maior representatividade na literatura acessada. Dentre as origens fúngicas, os fungos endofíticos apresentam destaque, representando 51% dos fungos descritos nesta revisão.
Recent studies warn of worsening in cases of neurodegenerative diseases with the increase in life expectancy of the world population. Due to the increase of neurological disorders such as Alzheimer, Parkinson and Amyotrophic Lateral Sclerosis, the search for new treatments are increasingly important. In this scenario, this work shows the potential of secondary fungal metabolites, especially from the phylum Ascomycota, as candidates in the search for therapeutic agents for neurodegenerative diseases and with action on neuroprotection. Through bibliographical research on the subject, from 2010 to 2020, the natural products of fungal origin reported in the literature were analyzed through the selection of important parameters such as biological action, chemical structure and biosynthetic classification. However, the curation of data of this work may assist in future investigations regarding the implementation of chemical and biological screenings more focused, with respect to bioprospecting of more promising targets, aiming at the development of therapeutic agents that can be used to combat diseases related to the human Nervous System. About 114 articles were selected and, through a screening and annotation process, a greater number of compounds with anti-inflammatory and antioxidant effects was observed. Results show that polyketides represent 44% of all compounds reviewed, being the most representative class of compounds in the literature accessed. Among the fungal origins, endophytic fungi stand out, representing 51% of the fungi described in this review.
Recent studies warn of worsening in cases of neurodegenerative diseases with the increase in life expectancy of the world population. Due to the increase of neurological disorders such as Alzheimer, Parkinson and Amyotrophic Lateral Sclerosis, the search for new treatments are increasingly important. In this scenario, this work shows the potential of secondary fungal metabolites, especially from the phylum Ascomycota, as candidates in the search for therapeutic agents for neurodegenerative diseases and with action on neuroprotection. Through bibliographical research on the subject, from 2010 to 2020, the natural products of fungal origin reported in the literature were analyzed through the selection of important parameters such as biological action, chemical structure and biosynthetic classification. However, the curation of data of this work may assist in future investigations regarding the implementation of chemical and biological screenings more focused, with respect to bioprospecting of more promising targets, aiming at the development of therapeutic agents that can be used to combat diseases related to the human Nervous System. About 114 articles were selected and, through a screening and annotation process, a greater number of compounds with anti-inflammatory and antioxidant effects was observed. Results show that polyketides represent 44% of all compounds reviewed, being the most representative class of compounds in the literature accessed. Among the fungal origins, endophytic fungi stand out, representing 51% of the fungi described in this review.