Ativos clareadores e nonoestruturas utilizadas em formulações para manejo de hipercromias
Data
2021-07-15
Autores
Rodrigues, Julia Costa [UNIFESP]
Orientadores
Filho, Newton Andréo [UNIFESP]
Tipo
Trabalho de conclusão de curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Os transtornos de hiperpigmentação são causas frequentes de procura a um
consultório médico dermatológico e os responsáveis pela movimentação de milhares
de dólares no mercado cosmético. O tratamento das manchas de pele oriundas destes
transtornos é determinado por uma série de variáveis como etnia, cor da pele e
sensibilidade aos compostos utilizados. Devido a alta demanda, os produtos com
propriedades clareadoras ocupam uma posição de destaque no mercado de
cosméticos e cosmecêuticos. A formulação destes produtos é desafiadora devido aos
diversos fatores que devem ser controlados ao formular ativos que tendem a ser
instáveis e sofrer interferências de outras substâncias da composição. Neste trabalho,
busca-se elucidar os mecanismos de ação dos ativos clareadores e o impacto de
diferentes nanoestruturas na melhora da estabilidade e entrega destes ativos na pele.
O uso de nanopartículas é capaz de melhorar a entrega destes ativos em tais
formulações.
Hyperpigmentation disorders are one of the most frequent causes of seeking a dermatological doctor’s office and the responsible for the movement of thousands of dollars in the cosmetic market. The treatment of skin spots derived from these disorders is determined by a number of variables such as ethnicity, skin color and sensitivity to the compounds used. Due to the high demand, products with whitening properties occupy a prominent position in the cosmetics and cosmeceuticals market. The formulation of these products is challenging due to the various factors that must be controlled when dealing with molecules that tend to be unstable and suffer interference from other substances used on cosmetics composition. In the present study, the aim is to elucidate the mechanisms of action of the bleaching actives and the use of nanostructures on stabilization and drug delivery of skin whitening substances. The usage of nanoparticles can enhance the effects of skin whitening agents by promoting a better drug delivery of those compounds.
Hyperpigmentation disorders are one of the most frequent causes of seeking a dermatological doctor’s office and the responsible for the movement of thousands of dollars in the cosmetic market. The treatment of skin spots derived from these disorders is determined by a number of variables such as ethnicity, skin color and sensitivity to the compounds used. Due to the high demand, products with whitening properties occupy a prominent position in the cosmetics and cosmeceuticals market. The formulation of these products is challenging due to the various factors that must be controlled when dealing with molecules that tend to be unstable and suffer interference from other substances used on cosmetics composition. In the present study, the aim is to elucidate the mechanisms of action of the bleaching actives and the use of nanostructures on stabilization and drug delivery of skin whitening substances. The usage of nanoparticles can enhance the effects of skin whitening agents by promoting a better drug delivery of those compounds.