Maternal Exercise during Pregnancy Increases BDNF Levels and Cell Numbers in the Hippocampal Formation but Not in the Cerebral Cortex of Adult Rat Offspring

Maternal Exercise during Pregnancy Increases BDNF Levels and Cell Numbers in the Hippocampal Formation but Not in the Cerebral Cortex of Adult Rat Offspring

Author da Silva, Sergio Gomes Autor UNIFESP Google Scholar
de Almeida, Alexandre Aparecido Autor UNIFESP Google Scholar
Fernandes, Jansen Autor UNIFESP Google Scholar
Lopim, Glauber Menezes Autor UNIFESP Google Scholar
Cabral, Francisco Romero Google Scholar
Scerni, Debora Amado Autor UNIFESP Google Scholar
de Oliveira-Pinto, Ana Virginia Google Scholar
Lent, Roberto Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Abstract Clinical evidence has shown that physical exercise during pregnancy may alter brain development and improve cognitive function of offspring. However, the mechanisms through which maternal exercise might promote such effects are not well understood. The present study examined levels of brain-derived neurotrophic factor (BDNF) and absolute cell numbers in the hippocampal formation and cerebral cortex of rat pups born from mothers exercised during pregnancy. Additionally, we evaluated the cognitive abilities of adult offspring in different behavioral paradigms (exploratory activity and habituation in open field tests, spatial memory in a water maze test, and aversive memory in a step-down inhibitory avoidance task). Results showed that maternal exercise during pregnancy increased BDNF levels and absolute numbers of neuronal and non-neuronal cells in the hippocampal formation of offspring. No differences in BDNF levels or cell numbers were detected in the cerebral cortex. It was also observed that offspring from exercised mothers exhibited better cognitive performance in nonassociative (habituation) and associative (spatial learning) mnemonic tasks than did offspring from sedentary mothers. Our findings indicate that maternal exercise during pregnancy enhances offspring cognitive function (habituation behavior and spatial learning) and increases BDNF levels and cell numbers in the hippocampal formation of offspring.
xmlui.dri2xhtml.METS-1.0.item-coverage San Francisco
Language English
Sponsor Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Instituto Nacional de Neurociencia Translacional (INNT, Brazil)
Grant number FAPESP: 09/06953-4
FAPESP: 10/11353-3
Date 2016
Published in Plos One. San Francisco, v. 11, n. 1, p. -, 2016.
ISSN 1932-6203 (Sherpa/Romeo, impact factor)
Publisher Public Library Science
Extent -
Origin https://doi.org/10.1371/journal.pone.0147200
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000368628300071
URI https://repositorio.unifesp.br/handle/11600/58554

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