Jucara pulp supplementation improves glucose tolerance in mice

Jucara pulp supplementation improves glucose tolerance in mice

Author Oyama, Lila Missae Autor UNIFESP Google Scholar
Silva, Fernanda Pinheiro da Autor UNIFESP Google Scholar
Carnier, June Autor UNIFESP Google Scholar
Miranda, Danielle Araujo de Autor UNIFESP Google Scholar
Santamarina, Aline Boveto Autor UNIFESP Google Scholar
Ribeiro, Eliane Beraldi Autor UNIFESP Google Scholar
Nascimento, Claudia Maria da Penha Oller do Autor UNIFESP Google Scholar
Rosso, Veridiana Vera de Autor UNIFESP Google Scholar
Abstract Background: The consumption of hyperlipidic and hypercaloric diet is considered a major factor to promote obesity and the consumption of food with antioxidant properties, like Jucara (Euterpe edulis Mart), could be a tool to prevent the deleterious effect of high white adipose deposition. The aim of the present study was to evaluate the effect of administration of jucara pulp in mice fed a high-fat, high-calorie diet on glucose tolerance and adipose tissue inflammatory status. Methods: Mice were distributed into the following groups: control diet; control diet plus 0.5 % of jucara; control diet plus 2 % of jucara; hypercaloric and hyperlipidic diet; hypercaloric and hyperlipidic diet plus 0.5 % of jucara and hypercaloric and hyperlipidic diet plus 2 % of jucara. Treatments started when mice were 8 weeks old and carried on for a total period of 10 weeks. The serum glucose, triacylglycerol, total cholesterol, insulin, adiponectin, lipopolysaccharides and free fatty acids concentrations were measured. Oral glucose tolerance test was performed. TNF-alpha, IL-6, and IL-10 protein level were determined by ELISA on mesenteric and epididymal white adipose tissues. Determination of catalase activity was realized in the same tissues. Data were analysed using one-way analysis of variance and post hoc analysis was performed with the Tukey's test. Results: The addition of 0.5 % jucara improved glycemic response in animals that consumed normocaloric as well as hypercaloric and hyperlipidic diets (HC). Supplementation with 0.5 and 2 % did not change the body composition of animals that received the HC diet; however, the animals fed the normocaloric diet with 2 % jucara gained body mass. An intake of 2 % jucara in the HC diet promoted a reduction of catalase activity and IL-10 level in epididymal adipose tissue. Conclusions: These results suggest that with the administration of 0.5 % jucara, the beneficial effects of polyphenols overcome the deleterious effects of macronutrient composition of jucara, whereas with the administration of 2 % jucara promotes damage by the composition of the fruit and overshadows the beneficial effects of polyphenols on glucose metabolism. On the other hand, higher jucara supplementation improves the inflammatory status targeted by the HC diet.
Keywords Jucara
Euterpe edulis Mart
Obesity
Inflammation
Mice
Anthocyanins
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2009/53884-8
FAPESP: 2013/12325-1
Date 2016
Published in Diabetology & Metabolic Syndrome. London, v. 8, p. -, 2016.
ISSN 1758-5996 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent -
Origin https://doi.org/10.1186/s13098-015-0122-4
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000368572700002
URI https://repositorio.unifesp.br/handle/11600/58542

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