Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses

Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses

Author Storm, Johan F. Google Scholar
Boly, Melanie Google Scholar
Casali, Adenauer G. Autor UNIFESP Google Scholar
Massimini, Marcello Google Scholar
Olcese, Umberto Google Scholar
Pennartz, Cyriel M. A. Google Scholar
Wilke, Melanie Google Scholar
Abstract How consciousness (experience) arises from and relates to material brain processes (the "mind-body problem") has been pondered by thinkers for centuries, and is regarded as among the deepest unsolved problems in science, with wide-ranging theoretical, clinical, and ethical implications. Until the last few decades, this was largely seen as a philosophical topic, but not widely accepted in mainstream neuroscience. Since the 1980s, however, novel methods and theoretical advances have yielded remarkable results, opening up the field for scientific and clinical progress. Since a seminal paper by Crick and Koch (1998) claimed that a science of consciousness should first search for its neural correlates (NCC), a variety of correlates have been suggested, including both content-specific NCCs, determining particular phenomenal components within an experience, and the full NCC, the neural substrates supporting entire conscious experiences. In this review, we present recent progress on theoretical, experimental, and clinical issues. Specifically, we (1) review methodological advances that are important for dissociating conscious experience from related enabling and executive functions, (2) suggest how critically reconsidering the role of the frontal cortex may further delineate NCCs, (3) advocate the need for general, objective, brain-based measures of the capacity for consciousness that are independent of sensory processing and executive functions, and (4) show how animal studies can reveal population and network phenomena of relevance for understanding mechanisms of consciousness.
Keywords brain complexity
content-specific NCC
functional connectivity
neural correlates of consciousness
no-report paradigm
Perturbational Complexity Index
unresponsive wakefulness
vegetative state
xmlui.dri2xhtml.METS-1.0.item-coverage Washington
Language English
Sponsor European Union's Horizon 2020 Research and Innovation Programme
Hermann and Lilly Schilling Foundation
German Research Foundation
Center for Nanoscale Microscopy and Molecular Physiology of the Brain
National Institutes of Health/National Institute of Neurological Disorders and Stroke
Sao Paulo Research Foundation
James S. McDonnell Foundation Scholar Award
EU Grant H2020-FETOPEN
Canadian Institute for Advanced Research
Azrieli Program in Brain, Mind and Consciousness
Norwegian Research Council
Netherlands Organization for Scientific Research
Grant number European Union's Horizon 2020 Research and Innovation Programme: 720270
German Research Foundation: WI 4046/1-1
National Institutes of Health/National Institute of Neurological Disorders and Stroke: 1R03NS096379
FAPESP: 2016/08263-9
EU Grant H2020-FETOPEN: RIA 686764
Date 2017
Published in Journal Of Neuroscience. Washington, v. 37, n. 45, p. 10882-10893, 2017.
ISSN 0270-6474 (Sherpa/Romeo, impact factor)
Publisher Soc Neuroscience
Extent 10882-10893
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000414662100014

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