Cardiac Autonomic Dysfunction in Offspring of Hypertensive Parents During Exercise

Cardiac Autonomic Dysfunction in Offspring of Hypertensive Parents During Exercise

Author de Almeida, Leonardo Barbosa Google Scholar
Pecanha, Tiago Google Scholar
de Carvalho Mira, Pedro Augusto Google Scholar
de Souza, Livia Victorino Autor UNIFESP Google Scholar
da Silva, Lilian Pinto Google Scholar
Martinez, Daniel Godoy Google Scholar
Guedes Freitas, Isabelle Magalhaes Google Scholar
Laterza, Mateus Camaroti Google Scholar
Abstract Offspring of hypertensive parents present autonomic dysfunction at rest and during physiological maneuvers. However, the cardiac autonomic modulation during exercise remains unknown. This study tested whether the cardiac autonomic modulation would be reduced in offspring of hypertensive parents during exercise. Fourteen offspring of hypertensive and 14 offspring of normotensive individuals were evaluated. The groups were matched by age (24.5 +/- 1.0 vs. 26.6 +/- 1.5 years; p=0.25) and BMI (22.8 +/- 0.6 vs. 24.2 +/- 1.0kg/m (2) ; p=0.30). Blood pressure and heart rate were assessed simultaneously during 3min at baseline followed by 3-min isometric handgrip at 30% of maximal voluntary contraction. Cardiac autonomic modulation was evaluated using heart rate variability. Primary variables were subjected to two-way ANOVA (group vs. time). P value<0.05 was considered statistically significant. Blood pressure and heart rate were similar between groups during exercise protocol. In contrast, offspring of hypertensive subjects showed a reduction of SDNN (Basal=34.8 +/- 3.5 vs. 45.2 +/- 3.7ms; Exercise=30.8 +/- 3.3 vs. 41.5 +/- 3.9ms; p group=0.01), RMSSD (Basal=37.1 +/- 3.7 vs. 52.0 +/- 6.0ms; Exercise=28.6 +/- 3.4 vs. 41.9 +/- 5.3ms; p group=0.02) and pNN50 (Basal=15.7 +/- 4.0 vs. 29.5 +/- 5.5%; Exercise=7.7 +/- 2.4 vs. 18.0 +/- 4.3%; p group=0.03) during the exercise protocol in comparison with offspring of normotensive parents. We concluded that normotensive offspring of hypertensive parents exhibit impaired cardiac autonomic modulation during exercise.
Keywords hypertension
autonomic nervous system
heredity
exercise
xmlui.dri2xhtml.METS-1.0.item-coverage Stuttgart
Language English
Sponsor Minas Gerais Research Foundation (FAPEMIG)
Date 2017
Published in International Journal Of Sports Medicine. Stuttgart, v. 38, n. 14, p. 1105-1110, 2017.
ISSN 0172-4622 (Sherpa/Romeo, impact factor)
Publisher Georg Thieme Verlag Kg
Extent 1105-1110
Origin http://dx.doi.org/10.1055/s-0043-119883
Access rights Closed access
Type Article
Web of Science ID WOS:000418457600008
URI https://repositorio.unifesp.br/handle/11600/58074

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