Induction of Labor using Misoprostol in a Tertiary Hospital in the Southeast of Brazil

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Godoy Silva, Tacito Augusto
Borges Junior, Luciano Eliziario
Tahan, Luisa Almeida
Arantes Costa, Taynna Ferreira
Magalhaes, Fernanda Oliveira
Peixoto, Alberto Borges
Martins, Wellington de Paula
Araujo Junior, Edward [UNIFESP]
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Purpose To assess cases of labor induction with vaginal 25-mu g tablets of misoprostol and maternal outcomes in a tertiary hospital in southeastern Brazil. Methods This was a retrospective cohort study of 412 pregnant women with indication for labor induction. Labor induction was performed with vaginal 25-mu g tablets ofmisoprostol in pregnant women with Bishop scores < 6. Stepwise regression analysis was used to identify the factors present at the beginning of induction that could be used as predictors of successful labor induction. Results A total of 69% of the pregnant women who underwent labor induction progressed to vaginal delivery, and 31% of the women progressed to cesarean section. One or two misoprostol tablets were used in 244 patients (59.2%). Of the 412 patients, 197 (47.8%) required oxytocin later on in the labor process, after induction with misoprostol. The stepwise regression analysis showed that only Bishop scores of 4 and 5 and previous vaginal delivery were independent factors with statistical significance in the prediction of successful vaginal labor induction (beta = 0.23, p < 0.001, for a Bishop score of 4 and 5, and beta = 0.22, p < 0.001, for previous vaginal delivery). Conclusion Higher Bishop scores and previous vaginal delivery were the best predictors of successful labor induction with vaginal 25-mu g tablets of misoprostol.
Revista Brasileira De Ginecologia E Obstetricia. Rio De Janeiro Rj, v. 39, n. 10, p. 523-528, 2017.