Effect of Statins on the Progression of Coronary Calcification in Kidney Transplant Recipients
Data
2016
Autores
Yazbek, Daniel Constantino 
Carvalho, Aluizio Barbosa de
Barros, Cinara Sa
Pestana, Jose Osmar Medina
Canziani, Maria Eugenia Fernandes
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Background Coronary calcification (CAC) is highly prevalent in kidney transplant recipients (KTRs) and has been associated with cardiovascular morbidity and mortality. Some studies have shown a reduction in CAC progression with statin therapy in the general and chronic kidney disease (CKD) populations. Objectives and Methods The aim of the present study was to evaluate the effect of statins on CAC progression in incident kidney transplant recipients. Patients were randomly assigned to the statin (n = 61, 10 mg daily) and control group (n = 59). CAC and biochemical analyses were performed at baseline and 12 months. Results At baseline, CAC was observed in 30% and 21% of patients in the statin and control groups, respectively (p = 0.39). The calcium score at baseline and its absolute and relative changes over 12 months of follow up were similar among the groups. In the statin group, total cholesterol (p < 0.001), low density lipoprotein cholesterol (p < 0.001) and triglycerides (p = 0.005) decreased, and the estimated glomerular function rate increased (p < 0.001) significantly. CRP levels remained stable (p = 0.52) in the statin group but increased in the control group (p = 0.01). In the multivariate model, there was no difference in CAC progression between the groups (group effect p = 0.034
time-effect p = 0.23
interaction p = 0.74). Similar results were obtained when only patients with >= 10AU calcium score (calcified) were analyzed (group effect p = 0.051
time-effect p = 0.58
interaction p = 0.99). Conclusion Although statins reduce the levels of cholesterol, triglycerides, inflammation and improve graft function, the dose adopted in the current study did not delay CAC progression within 12 months of follow up.
time-effect p = 0.23
interaction p = 0.74). Similar results were obtained when only patients with >= 10AU calcium score (calcified) were analyzed (group effect p = 0.051
time-effect p = 0.58
interaction p = 0.99). Conclusion Although statins reduce the levels of cholesterol, triglycerides, inflammation and improve graft function, the dose adopted in the current study did not delay CAC progression within 12 months of follow up.
Descrição
Citação
Plos One. San Francisco, v. 11, n. 4, p. -, 2016.