Square wave voltammetry of nitrofurans in aqueous media using a carbon fiber microelectrode

Square wave voltammetry of nitrofurans in aqueous media using a carbon fiber microelectrode

Author Chiavassa, Luisa Donatto Autor UNIFESP Google Scholar
La-Scalea, Mauro Aquiles Autor UNIFESP Google Scholar
Abstract The nitrofuran compounds exhibit a wide spectrum of biological action, and the understanding of their reduction mechanism can contribute to a better comprehension of their biological action. In this sense, the electrochemical reduction of nitrofurans has been studied through square wave voltammetry (SWV) in aqueous media, having a carbon fiber microelectrode as working electrode. One single cathodic peak in acidic media is registered for all studied drugs (nitrofurazone, nitrofurantoin, and furazolidone), being the hidroxylamine derivative formation linearly dependent on pH. In alkaline media, the peaks reduction is not pH-dependent, but a split of the original into two distinct peaks is observed. The evaluation of the results obtained in unprecedented form by SWV for different alkaline pH media, suggests that the charge transfer process for the R-NO2 center dot- formation is followed by irreversible chemical reaction, which chacraterizes an EC mechanism.
Keywords Nitrofurans
Square wave voltammetry
Carbon fiber microelectrode
EC mechanism
Nitro-anion radical
Alkaline aqueous media
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Date 2018
Published in Journal Of Solid State Electrochemistry. New York, v. 22, n. 5, p. 1395-1402, 2018.
ISSN 1432-8488 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 1395-1402
Origin http://dx.doi.org/10.1007/s10008-017-3751-8
Access rights Closed access
Type Article
Web of Science ID WOS:000430301800013
URI https://repositorio.unifesp.br/handle/11600/55583

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