Osteoporosis and autophagy: What is the relationship?

Osteoporosis and autophagy: What is the relationship?

Author Florencio-Silva, Rinaldo Autor UNIFESP Google Scholar
da Silva Sasso, Gisela Rodrigues Autor UNIFESP Google Scholar
Simoes, Manuel de Jesus Autor UNIFESP Google Scholar
Simoes, Ricardo Santos Google Scholar
Pinheiro Baracat, Maria Candida Google Scholar
Sasso-Cerri, Estela Google Scholar
Cerri, Paulo Sergio Google Scholar
Abstract Autophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting as a quality control process that prevents the accumulation of unnecessary structures and oxidative stress. Increasing evidence has shown that autophagy dysfunction is related to several pathologies including neurodegenerative diseases and cancer. Moreover, recent studies have shown that autophagy plays an important role for the maintenance of bone homeostasis. For instance, in vitro and animal and human studies indicate that autophagy dysfunction in bone cells is associated with the onset of bone diseases such as osteoporosis. This review had the purpose of discussing the issue to confirm whether a relationship between autophagy dysfunction and osteoporosis exits.
Keywords autophagy
bone tissue
osteoblast
osteocyte
osteoclast
osteoporosis
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo
Language English
Date 2017
Published in Revista Da Associacao Medica Brasileira. Sao Paulo, v. 63, n. 2, p. 173-179, 2017.
ISSN 0104-4230 (Sherpa/Romeo, impact factor)
Publisher Assoc Medica Brasileira
Extent 173-179
Origin http://dx.doi.org/10.1590/1806-9282.63.02.173
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000397875400013
URI https://repositorio.unifesp.br/handle/11600/55138

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