Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study

Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study

Author Blach, Sarah Google Scholar
Zeuzem, Stefan Google Scholar
Manns, Michael Google Scholar
Altraif, Ibrahim Google Scholar
Duberg, Ann-Sofi Google Scholar
Muljono, David H. Google Scholar
Waked, Imam Google Scholar
Alavian, Seyed M. Google Scholar
Lee, Mei-Hsuan Google Scholar
Negro, Francesco Google Scholar
Abaalkhail, Faisal Google Scholar
Abdou, Ahmed Google Scholar
Abdulla, Maheeba Google Scholar
Abou Rached, Antoine Google Scholar
Aho, Inka Google Scholar
Akarca, Ulus Google Scholar
Al Ghazzawi, Imad Google Scholar
Al Kaabi, Saad Google Scholar
Al Lawati, Faryal Google Scholar
Al Namaani, Khalid Google Scholar
Al Serkal, Youssif Google Scholar
Al-Busafi, Said A. Google Scholar
Al-Dabal, Layla Google Scholar
Aleman, Soo Google Scholar
Alghamdi, Abdullah S. Google Scholar
Aljumah, Abdulrahman A. Google Scholar
Al-Romaihi, Hamad E. Google Scholar
Andersson, Monique I. Google Scholar
Arendt, Vic Google Scholar
Arkkila, Perttu Google Scholar
Assiri, Abdullah M. Google Scholar
Baatarkhuu, Oidov Google Scholar
Bane, Abate Google Scholar
Ben-Ari, Ziv Google Scholar
Bergin, Colm Google Scholar
Bessone, Fernando Google Scholar
Bihl, Florian Google Scholar
Bizri, Abdul R. Google Scholar
Blachier, Martin Google Scholar
Blasco, Antonio J. Google Scholar
Mello, Carlos E. Brandao Google Scholar
Bruggmann, Philip Google Scholar
Brunton, Cheryl R. Google Scholar
Calinas, Filipe Google Scholar
Chan, Henry L. Y. Google Scholar
Chaudhry, Asad Google Scholar
Cheinquer, Hugo Google Scholar
Chen, Chien-Jen Google Scholar
Chien, Rong-Nan Google Scholar
Choi, Moon Seok Google Scholar
Christensen, Peer B. Google Scholar
Chuang, Wan-Long Google Scholar
Chulanov, Vladimir Google Scholar
Cisneros, Laura Google Scholar
Clausen, Mette R. Google Scholar
Cramp, Matthew E. Google Scholar
Craxi, Antonio Google Scholar
Croes, Esther A. Google Scholar
Dalgard, Olav Google Scholar
Daruich, Jorge R. Google Scholar
de Ledinghen, Victor Google Scholar
Dore, Gregory J. Google Scholar
El-Sayed, Manal H. Google Scholar
Ergor, Gul Google Scholar
Esmat, Gamal Google Scholar
Estes, Chris Google Scholar
Falconer, Karolin Google Scholar
Farag, Elmoubashar Google Scholar
Ferraz, Maria L. G. Autor UNIFESP Google Scholar
Autor UNIFESP Google Scholar
Flisiak, Robert Google Scholar
Frankova, Sona Google Scholar
Gamkrelidze, Ivane Google Scholar
Gane, Ed Google Scholar
Garcia-Samaniego, Javier Google Scholar
Khan, Amir Ghafoor Google Scholar
Gountas, Ilias Google Scholar
Goldis, Adrian Google Scholar
Gottfredsson, Magnus Google Scholar
Grebely, Jason Google Scholar
Gschwantler, Michael Google Scholar
Pessoa, Mario Guimaraes Google Scholar
Gunter, Jessie Google Scholar
Hajarizadeh, Behzad Google Scholar
Hajelssedig, Omer Google Scholar
Hamid, Saeed Google Scholar
Hamoudi, Waseem Google Scholar
Hatzakis, Angelos Google Scholar
Himatt, Sayed M. Google Scholar
Hofer, Harald Google Scholar
Hrstic, Irena Google Scholar
Hui, Yee-Tak Google Scholar
Hunyady, Bela Google Scholar
Idilman, Ramazan Google Scholar
Jafri, Wasim Google Scholar
Jahis, Rohani Google Scholar
Janjua, Naveed Z. Google Scholar
Jarcuska, Peter Google Scholar
Jeruma, Agita Google Scholar
Jonasson, Jon G. Google Scholar
Kamel, Yasser Google Scholar
Kao, Jia-Horng Google Scholar
Kaymakoglu, Sabahattin Google Scholar
Kershenobich, David Google Scholar
Khamis, Jawad Google Scholar
Kim, Young S. Google Scholar
Kondili, Loreta Google Scholar
Koutoubi, Zaher Google Scholar
Krajden, Mel Google Scholar
Krarup, Henrik Google Scholar
Lai, Moon-sing Google Scholar
Laleman, Wim Google Scholar
Lao, Wai-cheung Google Scholar
Lavanchy, Daniel Google Scholar
Lazaro, Pablo Google Scholar
Leleu, Henri Google Scholar
Lesi, Olufunmilayo Google Scholar
Lesmana, Laurentius A. Google Scholar
Li, Michael Google Scholar
Liakina, Valentina Google Scholar
Lim, Young-Suk Google Scholar
Luksic, Boris Google Scholar
Mahomed, Adam Google Scholar
Maimets, Matti Google Scholar
Makara, Mihaly Google Scholar
Malu, Abraham O. Google Scholar
Marinho, Rui T. Google Scholar
Marotta, Paul Google Scholar
Mauss, Stefan Google Scholar
Memon, Muhammad S. Google Scholar
Correa, Maria C. Mendes Google Scholar
Mendez-Sanchez, Nahum Google Scholar
Merat, Shahin Google Scholar
Metwally, Ammal M. Google Scholar
Mohamed, Rosmawati Google Scholar
Moreno, Christophe Google Scholar
Mourad, Fadi H. Google Scholar
Mullhaupt, Beat Google Scholar
Murphy, Kimberly Google Scholar
Nde, Helen Google Scholar
Njouom, Richard Google Scholar
Nonkovic, Diana Google Scholar
Norris, Suzanne Google Scholar
Obekpa, Solomon Google Scholar
Oguche, Stephen Google Scholar
Olafsson, Sigurour Google Scholar
Oltman, Marian Google Scholar
Omede, Ogu Google Scholar
Omuemu, Casimir Google Scholar
Opare-Sem, Ohene Google Scholar
Ovrehus, Anne L. H. Google Scholar
Owusu-Ofori, Shirley Google Scholar
Oyunsuren, Tsendsuren S. Google Scholar
Papatheodoridis, George Google Scholar
Pasini, Ken Google Scholar
Peltekian, Kevork M. Google Scholar
Phillips, Richard O. Google Scholar
Pimenov, Nikolay Google Scholar
Poustchi, Hossein Google Scholar
Prabdial-Sing, Nishi Google Scholar
Qureshi, Huma Google Scholar
Ramji, Alnoor Google Scholar
Razavi-Shearer, Devin Google Scholar
Razavi-Shearer, Kathryn Google Scholar
Redae, Berhane Google Scholar
Reesink, Henk W. Google Scholar
Ridruejo, Ezequiel Google Scholar
Robbins, Sarah Google Scholar
Roberts, Lewis R. Google Scholar
Roberts, Stuart K. Google Scholar
Rosenberg, William M. Google Scholar
Roudot-Thoraval, Francoise Google Scholar
Ryder, Stephen D. Google Scholar
Safadi, Rifaat Google Scholar
Sagalova, Olga Google Scholar
Salupere, Riina Google Scholar
Sanai, Faisal M. Google Scholar
Avila, Juan F. Sanchez Google Scholar
Saraswat, Vivek Google Scholar
Sarmento-Castro, Rui Google Scholar
Sarrazin, Christoph Google Scholar
Schmelzer, Jonathan D. Google Scholar
Schreter, Ivan Google Scholar
Seguin-Devaux, Carole Google Scholar
Shah, Samir R. Google Scholar
Sharara, Ala I. Google Scholar
Sharma, Manik Google Scholar
Shevaldin, Anatoly Google Scholar
Shiha, Gamal E. Google Scholar
Sievert, William Google Scholar
Sonderup, Mark Google Scholar
Souliotis, Kyriakos Google Scholar
Speiciene, Danute Google Scholar
Sperl, Jan Google Scholar
Starkel, Peter Google Scholar
Stauber, Rudolf E. Google Scholar
Stedman, Catherine Google Scholar
Struck, Daniel Google Scholar
Su, Tung-Hung Google Scholar
Sypsa, Vana Google Scholar
Tan, Soek-Siam Google Scholar
Tanaka, Junko Google Scholar
Thompson, Alexander J. Google Scholar
Tolmane, Ieva Google Scholar
Tomasiewicz, Krzysztof Google Scholar
Valantinas, Jonas Google Scholar
Van Damme, Pierre Google Scholar
van der Meer, Adriaan J. Google Scholar
van Thiel, Ingo Google Scholar
Van Vlierberghe, Hans Google Scholar
Vince, Adriana Google Scholar
Vogel, Wolfgang Google Scholar
Wedemeyer, Heiner Google Scholar
Weis, Nina Google Scholar
Wong, Vincent W. S. Google Scholar
Yaghi, Cesar Google Scholar
Yosry, Ayman Google Scholar
Yuen, Man-fung Google Scholar
Yunihastuti, Evy Google Scholar
Yusuf, Aasim Google Scholar
Zuckerman, Eli Google Scholar
Razavi, Homie Google Scholar
Abstract Background The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate hepatitis C virus (HCV) infection by 2030, which can become a reality with the recent launch of direct acting antiviral therapies. Reliable disease burden estimates are required for national strategies. This analysis estimates the global prevalence of viraemic HCV at the end of 2015, an update of-and expansion on-the 2014 analysis, which reported 80 million (95% CI 64-103) viraemic infections in 2013. Methods We developed country-level disease burden models following a systematic review of HCV prevalence (number of studies, n=6754) and genotype (n=11 342) studies published after 2013. A Delphi process was used to gain country expert consensus and validate inputs. Published estimates alone were used for countries where expert panel meetings could not be scheduled. Global prevalence was estimated using regional averages for countries without data. Findings Models were built for 100 countries, 59 of which were approved by country experts, with the remaining 41 estimated using published data alone. The remaining countries had insufficient data to create a model. The global prevalence of viraemic HCV is estimated to be 1.0% (95% uncertainty interval 0.8-1.1) in 2015, corresponding to 71.1 million (62.5-79.4) viraemic infections. Genotypes 1 and 3 were the most common cause of infections (44% and 25%, respectively). Interpretation The global estimate of viraemic infections is lower than previous estimates, largely due to more recent (lower) prevalence estimates in Africa. Additionally, increased mortality due to liver-related causes and an ageing population may have contributed to a reduction in infections.
xmlui.dri2xhtml.METS-1.0.item-coverage San Diego
Language English
Sponsor John C Martin Foundation
Date 2017
Published in Lancet Gastroenterology & Hepatology. San Diego, v. 2, n. 3, p. 161-176, 2017.
ISSN 2468-1253 (Sherpa/Romeo, impact factor)
Publisher Elsevier Inc
Extent 161-176
Origin http://dx.doi.org/10.1016/S2468-1253(16)30181-9
Access rights Closed access
Type Article
Web of Science ID WOS:000426979400014
URI https://repositorio.unifesp.br/handle/11600/55087

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