Intra-articular injection with triamcinolone hexacetonide in patients with rheumatoid arthritis: prospective assessment of goniometry and joint inflammation parameters
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Data
2017
Autores
Vilar Furtado, Rita Nely [UNIFESP]
Machado, Flavia Soares [UNIFESP]
da Luz, Karine Rodrigues [UNIFESP]
dos Santos, Marla Francisca [UNIFESP]
Konai, Monique Sayuri [UNIFESP]
Lopes, Roberta Vilela [UNIFESP]
Natour, Jamil [UNIFESP]
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Objectives: To evaluate local joint variables after intra-articular injection (IAI) with triamcinolone hexacetonide (HT) in rheumatoid arthritis (RA) patients. Methods: We blindly and prospectively (baseline, 1, 4, 12 and 24 weeks) evaluated metacarpophalangeal (MCP), wrist, elbow, shoulder, knee and ankle joints after HT IAI by the following outcome measures: Visual analogue scale 0-10 cm (VAS) for rest pain (VASR)
VAS for movement pain (VASM)
VAS for joint swelling (VASSw)
flexion (FlexG) and extension (ExtG). Results: 289 patients (635 joints) were studied. VASSw (p < 0,001) and VASR (0,001< p < 0.016) improved from TO to T4, T12 and T24 for all joints. VASM improved from TO-T4 (p < 0.021) for all joints
TO-T12 (p < 0.023) for MCF and knee
TO-T24 (p < 0.019) only for MCF and knee. FlexG improved from TO-T4 (p < 0.001) for all joints
TO-T12 (p < 0.001) and TO-T24 (p < 0.02) only for MCF and knee. ExtG improved from TO-T4 (p < 0.001) for all joints except for elbow
TO-T12 (p = 0.003) for wrist, MCP and knee
and TO-T24 (p = 0.014) for MCF and knee. Conclusion: VASSw responded better at short and medium term after IAI with HT in our sample of RA patients. (C) 2016 Published by Elsevier Editora Ltda.
VAS for movement pain (VASM)
VAS for joint swelling (VASSw)
flexion (FlexG) and extension (ExtG). Results: 289 patients (635 joints) were studied. VASSw (p < 0,001) and VASR (0,001< p < 0.016) improved from TO to T4, T12 and T24 for all joints. VASM improved from TO-T4 (p < 0.021) for all joints
TO-T12 (p < 0.023) for MCF and knee
TO-T24 (p < 0.019) only for MCF and knee. FlexG improved from TO-T4 (p < 0.001) for all joints
TO-T12 (p < 0.001) and TO-T24 (p < 0.02) only for MCF and knee. ExtG improved from TO-T4 (p < 0.001) for all joints except for elbow
TO-T12 (p = 0.003) for wrist, MCP and knee
and TO-T24 (p = 0.014) for MCF and knee. Conclusion: VASSw responded better at short and medium term after IAI with HT in our sample of RA patients. (C) 2016 Published by Elsevier Editora Ltda.
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Revista Brasileira De Reumatologia. New York, v. 57, n. 2, p. 115-121, 2017.