Remission of acromegaly after treatment withdrawal in patients controlled by cabergoline alone or in combination with octreotide: results from a multicenter study

Remission of acromegaly after treatment withdrawal in patients controlled by cabergoline alone or in combination with octreotide: results from a multicenter study

Author Casagrande, A. Autor UNIFESP Google Scholar
Bronstein, M. D. Google Scholar
Jallad, R. S. Google Scholar
Mota, J. I. Google Scholar
Tabet, A. Google Scholar
Abucham, J. Autor UNIFESP Google Scholar
Abstract Purpose Remission of acromegaly has been reported after somatostatin analogs withdrawal, but not after withdrawal of combination therapy with cabergoline, and only in case reports of patients controlled by cabergoline alone. Methods To establish the remission rates (normal IGF-1 for age/sex: IGF-1 <= 1.00 xULN) after withdrawal of combined treatment with octreotide LAR and cabergoline and of cabergoline alone, we prospectively studied 16 patients with acromegaly controlled by those treatments in the preceding 2 years as part of a larger study on remission of acromegaly after withdrawal of different medical treatments. Results Among 97 patients with controlled acromegaly included in the entire study, only 16 patients had been on combination therapy (n = 12) or cabergoline alone (n = 4). At 8 weeks after treatment withdrawal, three patients (19%) were in remission (short-term remission). At 60 weeks (long-term remission), IGF-1 levels were still in the normal range in two patients (12.5%) and remained normal up to 108 weeks after treatment withdrawal (last visit). One patient had been treated with cabergoline alone and another one with combination of octreotide and cabergoline before treatment withdrawal. Conclusion Remission of acromegaly after treatment withdrawal seems to be uncommon in patients controlled by cabergoline, either as monotherapy or in combination with octreotide. In the future, larger studies and/or meta-analysis will be necessary to accurately establish the remission rates of acromegaly after withdrawal of cabergoline with or without somatostatin analogs.
Keywords Acromegaly
Combination therapy
Remission
Octreotide
Cabergoline
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (BR)
Grant number CAPES: 528/11
Date 2017
Published in Journal Of Endocrinological Investigation. New York, v. 40, n. 5, p. 523-528, 2017.
ISSN 1720-8386 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 523-528
Origin http://dx.doi.org/10.1007/s40618-016-0595-5
Access rights Closed access
Type Article
Web of Science ID WOS:000399306000009
URI https://repositorio.unifesp.br/handle/11600/54690

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