Exercise training versus T3 and T4 hormones treatment: The differential benefits of thyroid hormones on the parasympathetic drive of infarcted rats

Exercise training versus T3 and T4 hormones treatment: The differential benefits of thyroid hormones on the parasympathetic drive of infarcted rats

Author Teixeira, Rayane Brinck Google Scholar
Zimmer, Alexsandra Google Scholar
de Castro, Alexandre Luz Google Scholar
Carraro, Cristina Campos Google Scholar
Casali, Karina Rabello Autor UNIFESP Google Scholar
Machuca Dias, Ingrid Goncalves [UNIFEP] Google Scholar
Guerra Godoy, Alessandra Eifler Google Scholar
Litvin, Isnard Elman Google Scholar
Bello-Klein, Adriane Google Scholar
da Rosa Araujo, Alex Sander Google Scholar
Abstract Aims: This study aimed to investigate whether beneficial effects of thyroid hormones are comparable to those provided by the aerobic exercise training, to verify its applicability as a therapeutic alternative to reverse the pathological cardiac remodeling post-infarction. Materials and methods: Male rats were divided into SHAM-operated (SHAM), myocardial infarction (MI), MI subjected to exercise training (MIE), and MI who received T3 and T4 treatment (MIH) (n=8/group). MI, MIE and MIH groups underwent an infarction surgery while SHAM was SHAM-operated. One-week post-surgery, MIE and MIH groups started the exercise training protocol (moderate intensity on treadmill), or the T3 (1.2 mu g/100 g/day) and T4 (4.8 mu g/100 g/day) hormones treatment by gavage, respectively, meanwhile SHAM and MI had no intervention for 9 weeks. The groups were accompanied until 74 days after surgery, when all animals were anesthetized, left ventricle echocardiography and femoral catheterization were performed, followed by euthanasia and left ventricle collection for morphological, oxidative stress, and intracellular kinases expression analysis. Key findings: Thyroid hormones treatment was more effective in cardiac dilation and infarction area reduction, while exercise training provided more protection against fibrosis. Thyroid hormones treatment increased the lipoperoxidation and decreased GSHPx activity as compared to MI group, increased the t-Akt2 expression as compared to SHAM group, and increased the vascular parasympathetic drive. Significance: Thyroid hormones treatment provided differential benefits on the LV function and autonomic modulation as compared to the exercise training. Nevertheless, the redox unbalance induced by thyroid hormones highlights the importance of more studies targeting the ideal duration of this treatment.
Keywords Acute myocardial infarction
Exercise training
Thyroid hormones
Parasympathetic drive
Left ventricle function
Oxidative stress
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor CNPq
Grant number CNPq [142025/2015-1]
Date 2018
Published in Life Sciences. Oxford, v. 196, p. 93-101, 2018.
ISSN 0024-3205 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 93-101
Origin http://dx.doi.org/10.1016/j.lfs.2018.01.018
Access rights Closed access
Type Article
Web of Science ID WOS:000425851500012
URI https://repositorio.unifesp.br/handle/11600/54073

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