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dc.contributor.authorAlmeida Monteiro De Moraes, Wilson Max [UNIFESP]
dc.contributor.authorMoraes de Souza, Pamella Ramona
dc.contributor.authorda Paixao, Nathalie Alves
dc.contributor.authorOliveira de Sousa, Luis Gustavo
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.authorMarshall, Andrea G.
dc.contributor.authorPrestes, Jonato
dc.contributor.authorIrigoyen, Maria Claudia
dc.contributor.authorBrum, Patricia Chakur
dc.contributor.authorMedeiros, Alessandra [UNIFESP]
dc.identifier.citationJournal Of Cellular And Molecular Medicine. Hoboken, v. 22, n. 3, p. 1452-1463, 2018.
dc.description.abstractWe tested whether aerobic exercise training (AET) would modulate the skeletal muscle protein quality control (PQC) in a model of chronic kidney disease (CKD) in rats. Adult Wistar rats were evaluated in four groups: control (CS) or trained (CE), and 5/6 nephrectomy sedentary (5/6NxS) or trained (5/6NxE). Exercised rats were submitted to treadmill exercise (60min., five times/wk for 2months). We evaluated motor performance (tolerance to exercise on the treadmill and rotarod), cross-sectional area (CSA), gene and protein levels related to the unfolded protein response (UPR), protein synthesis/survive and apoptosis signalling, accumulated misfolded proteins, chymotrypsin-like proteasome activity (UPS activity), redox balance and heat-shock protein (HSP) levels in the tibialis anterior. 5/6NxS presented a trend towards to atrophy, with a reduction in motor performance, down-regulation of protein synthesis and up-regulation of apoptosis signallingen
dc.description.abstractincreases in UPS activity, misfolded proteins, GRP78, derlin, HSP27 and HSP70 protein levels, ATF4 and GRP78 genesen
dc.description.abstractand increase in oxidative damage compared to CS group. In 5/6NxE, we observed a restoration in exercise tolerance, accumulated misfolded proteins, UPS activity, protein synthesis/apoptosis signalling, derlin, HSPs protein levels as well as increase in ATF4, GRP78 genes and ATF6 protein levels accompanied by a decrease in oxidative damage and increased catalase and glutathione peroxidase activities. The results suggest a disruption of PQC in white muscle fibres of CKD rats previous to the atrophy. AET can rescue this disruption for the UPR, prevent accumulated misfolded proteins and reduce oxidative damage, HSPs protein levels and exercise tolerance.en
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipFundacao de Amparoa Pesquisa do Estado de Sao Paulo (FAPESP)
dc.relation.ispartofJournal Of Cellular And Molecular Medicine
dc.rightsAcesso aberto
dc.subjectchronic kidney diseaseen
dc.subjectaerobic exercise trainingen
dc.subjectskeletal muscleen
dc.subjectprotein quality controlen
dc.subjectunfolded protein responseen
dc.titleAerobic exercise training rescues protein quality control disruption on white skeletal muscle induced by chronic kidney disease in ratsen
dc.description.affiliationUniv Fed Sao Paulo, Biosci Dept, Santos, Brazil
dc.description.affiliationCatholic Univ Brasilia UCB, Postgrad Program Phys Educ, Brasilia, DF, Brazil
dc.description.affiliationNove de Julho Univ UNINOVE, Dept Postgrad Med, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, Sao Paulo, Brazil
dc.description.affiliationUniv Calif Davis, Dept Neurobiol Physiol & Behav, Davis, CA 95616 USA
dc.description.affiliationUniv Sao Paulo, Sch Med, Inst Heart, Hypertens Unit, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Biosci Dept, Santos, Brazil
dc.description.sponsorshipIDCAPES: 12/51090-1
dc.description.sponsorshipIDFAPESP: 15/198936-0
dc.description.sourceWeb of Science

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