Chemical composition and biological activities of Guatteria elliptica R. E. Fries (Annonaceae) essential oils
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2018
Autores
Rajca Ferreira, Agnieszka Katarzyna
Lourenco, Felipe Rebello
Marx Young, Maria Claudia
Leite Lima, Marcos Enoque
Cordeiro, Ines
Suffredini, Ivana Barbosa
Lopes, Patricia Santos [UNIFESP]
Hrihorowitsch Moreno, Paulo Roberto
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Leaf from two Guatteria elliptica R. E. Fries (Annonaceae) specimens were collected at Paranapiacaba and Caraguatatuba in Sao Paulo (Brazil). The essential oils presented (GC/GC-MS), as major compound, spathulenol (53.9%) for the Paranapiacaba specimen and caryophyllene oxide (40.9%) for Caraguatatuba. The oils showed low antioxidant activity with EC50 = 7.24 +/- 1.03 and 28.68 +/- 5.78 mg/mL, respectively, for Paranapiacaba and Caraguatatuba specimens. Both oils did not show a relevant (MIC > 3 mg/mL) antimicrobial activity. However, the Paranapiacaba oil presented an important antitumour activity against breast and prostate cancer cells (IC50 = 7.01 +/- 0.23 and 5.35 +/- 0.35 mu g/mL, respectively) and a low cytotoxicity against normal fibroblast cells (IC50 > 22.27 e IC10 = 18.55 +/- 1.89 mu g/mL). Isolated major compound, spathulenol, showed good activity against MCF-7 and PC-3 with IC50 = 5.38 +/- 0.20 and 2.25 +/- 0.28 mu g/mL mu g/mL, respectively.
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Journal Of Essential Oil Research. Philadelphia, v. 30, n. 1, p. 69-76, 2018.