Chemical composition and biological activities of Guatteria elliptica R. E. Fries (Annonaceae) essential oils
Rajca Ferreira, Agnieszka Katarzyna
Lourenco, Felipe Rebello
Marx Young, Maria Claudia
Leite Lima, Marcos Enoque
Suffredini, Ivana Barbosa
Lopes, Patricia Santos [UNIFESP]
Hrihorowitsch Moreno, Paulo Roberto
Is part ofJournal Of Essential Oil Research
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Leaf from two Guatteria elliptica R. E. Fries (Annonaceae) specimens were collected at Paranapiacaba and Caraguatatuba in Sao Paulo (Brazil). The essential oils presented (GC/GC-MS), as major compound, spathulenol (53.9%) for the Paranapiacaba specimen and caryophyllene oxide (40.9%) for Caraguatatuba. The oils showed low antioxidant activity with EC50 = 7.24 +/- 1.03 and 28.68 +/- 5.78 mg/mL, respectively, for Paranapiacaba and Caraguatatuba specimens. Both oils did not show a relevant (MIC > 3 mg/mL) antimicrobial activity. However, the Paranapiacaba oil presented an important antitumour activity against breast and prostate cancer cells (IC50 = 7.01 +/- 0.23 and 5.35 +/- 0.35 mu g/mL, respectively) and a low cytotoxicity against normal fibroblast cells (IC50 > 22.27 e IC10 = 18.55 +/- 1.89 mu g/mL). Isolated major compound, spathulenol, showed good activity against MCF-7 and PC-3 with IC50 = 5.38 +/- 0.20 and 2.25 +/- 0.28 mu g/mL mu g/mL, respectively.
CitationJournal Of Essential Oil Research. Philadelphia, v. 30, n. 1, p. 69-76, 2018.
essential oils composition
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