Fish Oil Supplementation Reduces Heart Levels of Interleukin-6 in Rats with Chronic Inflammation due to Epilepsy

Fish Oil Supplementation Reduces Heart Levels of Interleukin-6 in Rats with Chronic Inflammation due to Epilepsy

Author Nejm, Mariana Bocca Autor UNIFESP Google Scholar
Abou Haidar, Andre Autor UNIFESP Google Scholar
Hirata, Aparecida Emiko Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
de Almeida, Antonio-Carlos Guimaraes Google Scholar
Cysneiros, Roberta Monterazzo Google Scholar
Cavalheiro, Esper Abrao Autor UNIFESP Google Scholar
Scorza, Carla Alessandra Autor UNIFESP Google Scholar
Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Abstract Sudden unexpected death in epilepsy (SUDEP) is a major cause of premature death related to epilepsy. The causes of SUDEP remain unknown, but cardiac arrhythmias and asphyxia have been suggested as a major mechanism of this event. Inflammation has been implicated in the pathogenesis of both epilepsy and ventricular arrhythmia, with interleukin-6 (IL-6) being recognized as a crucial orchestrator of inflammatory states. Our group previously reported that levels of IL-6 were increased in the hearts of epileptic rats. In this scenario, anti-inflammatory actions are among the beneficial effects of fish oil dietary supplementation. This investigation revealed that elevated levels of IL-6 in the heart were markedly reduced in epileptic rats that were treated in the long-term with fish oil, suggesting protective anti-inflammatory actions against dangerously high levels of IL-6. Based on these findings, our results suggest beneficial effects of long-term intake of fish oil in reducing the inflammation associated with chronic epilepsy.
Keywords epilepsy
sudden unexpected death in epilepsy
inflammation
heart
interleukin-6
fish oil
xmlui.dri2xhtml.METS-1.0.item-coverage Lausanne
Language English
Sponsor FAPESP
CAPES
CNPq
FAPESP/CNPq/MCT-Instituto Nacional de Neurociencia Translacional
FAPEMIG
CEPID/FAPESP
Grant number FAPESP
CAPES
CNPq
FAPESP/CNPq/MCT-Instituto Nacional de Neurociencia Translacional
FAPEMIG
CEPID/FAPESP
Date 2017
Published in Frontiers In Neurology. Lausanne, v. 8, p. -, 2017.
ISSN 1664-2295 (Sherpa/Romeo, impact factor)
Publisher Frontiers Media Sa
Extent -
Origin http://dx.doi.org/10.3389/fneur.2017.00263
Access rights ACESSO ABERTO
Type Article
Web of Science ID WOS:000403389100002
URI https://repositorio.unifesp.br/handle/11600/53663

Show full item record




File

Name: WOS000403389100002.pdf
Size: 239.0Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account