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Combination of a high-fat diet with sweetened condensed milk exacerbates inflammation and insulin resistance induced by each separately in mice

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Date
2017
Author
Masi, Laureane Nunes
Martins, Amanda Roque
Crisma, Amanda Rabello
Amaral, Catia Lira do
Davanso, Mariana Rodrigues
Afonso Serdan, Tamires Duarte
Sá, Roberta Dourado Cavalcante da Cunha de [UNIFESP]
Cruz, Maysa Mariana [UNIFESP]
Alonso-Vale, Maria Isabel Cardoso [UNIFESP]
Torres, Rosângela Pavan
Mancini-Filho, Jorge
Bertaglia Pereira, Joice Naiara
da Silva Righetti, Marta Maria
Liberti, Edson Aparecido
Hirabara, Sandro Massao
Curi, Rui
Type
Artigo
ISSN
2045-2322
Is part of
Scientific Reports
DOI
10.1038/s41598-017-04308-1
Metadata
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Abstract
Obesogenic diets increase body weight and cause insulin resistance (IR), however, the association of these changes with the main macronutrient in the diet remains to be elucidated. Male C57BL/6 mice were fed with: control (CD), CD and sweetened condensed milk (HS), high-fat (HF), and HF and condensed milk (HSHF). After 2 months, increased body weight, glucose intolerance, adipocyte size and cholesterol levels were observed. As compared with CD, HS ingested the same amount of calories whereas HF and HSHF ingested less. HS had increased plasma AST activity and liver type I collagen. HF caused mild liver steatosis and hepatocellular damage. HF and HSHF increased LDL-cholesterol, hepatocyte and adipocyte hypertrophy, TNF-alpha by macrophages and decreased lipogenesis and adiponectin in adipose tissue (AT). HSHF exacerbated these effects, increasing IR, lipolysis, mRNA expression of F4/80 and leptin in AT, Tlr-4 in soleus muscle and IL-6, IL-1 beta, VCAM-1, and ICAM-1 protein in AT. The three obesogenic diets induced obesity and metabolic dysfunction. HS was more proinflammatory than the HF and induced hepatic fibrosis. The HF was more detrimental in terms of insulin sensitivity, and it caused liver steatosis. The combination HSHF exacerbated the effects of each separately on insulin resistance and AT inflammatory state.
Citation
Scientific Reports. London, v. 7, p. -, 2017.
Sponsorship
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Guggenheim Foundation
URI
https://repositorio.unifesp.br/handle/11600/53643
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  • EPM - Artigos [16303]

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