Contribution of Molecular Allergen Analysis in Diagnosis of Milk Allergy

Date
2017Author
Bartuzi, Zbigniew
Cocco, Renata Rodrigues [UNIFESP]
Muraro, Antonella
Nowak-Wegrzyn, Anna
Type
ArtigoISSN
1529-7322Is part of
Current Allergy And Asthma ReportsDOI
10.1007/s11882-017-0716-zMetadata
Show full item recordAbstract
Purpose of Review We sought to describe the available evidence supporting the utilization of the molecular allergen analysis (MAA) for diagnosis and management of cow milk protein allergy (CMPA). Recent Findings Cow milk proteins are among the most common food allergens in IgE- and non-IgE-mediated food allergic disorders in children. Most individuals with CMPA are sensitized to both caseins and whey proteins. Caseins are more resistant to high temperatures compared to whey proteins. Summary MAA is not superior to the conventional diagnostic tests based on the whole allergen extracts for diagnosis of CMPA. However, MAA can be useful in diagnosing tolerance to extensively heated milk proteins in baked foods. Children with CMPA and high levels of casein IgE are less likely to tolerate baked milk compared to children with low levels of casein IgE. Specific IgE-binding patterns to casein and betalactoglobulin peptides may predict the natural course of CMPA and differentiate subjects who are more likely to develop CMPA at a younger age versus those with a more persistent CMPA. Specific IgE-binding patterns to casein and beta-lactoglobulin peptides may also predict response to milk OIT and identify patients most likely to benefit from OIT.
Citation
Current Allergy And Asthma Reports. Philadelphia, v. 17, n. 7, p. -, 2017.Keywords
Baked milk dietCasein
Cow milk allergy
Milk allergy
Molecular allergen analysis
Molecular diagnosis
Whey proteins
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- EPM - Artigos [17701]