TFOS DEWS II Management and Therapy Report

TFOS DEWS II Management and Therapy Report

Author Jones, Lyndon Google Scholar
Downie, Laura E. Google Scholar
Korb, Donald Google Scholar
Benitez-del-Castillo, Jose M. Google Scholar
Dana, Reza Google Scholar
Deng, Sophie X. Google Scholar
Dong, Pham N. Google Scholar
Geerling, Gerd Google Scholar
Hida, Richard Yudi Google Scholar
Liu, Yang Google Scholar
Seo, Kyoung Yul Google Scholar
Tauber, Joseph Google Scholar
Wakamatsu, Tais H. Autor UNIFESP Google Scholar
Xu, Jianjiang Google Scholar
Wolffsohn, James S. Google Scholar
Craig, Jennifer P. Google Scholar
Abstract The members of the Management and Therapy Subcommittee undertook an evidence-based review of current dry eye therapies and management options. Management options reviewed in detail included treatments for tear insufficiency and lid abnormalities, as well as anti-inflammatory medications, surgical approaches, dietary modifications, environmental considerations and complementary therapies. Following this extensive review it became clear that many of the treatments available for the management of dry eye disease lack the necessary Level 1 evidence to support their recommendation, often due to a lack of appropriate masking, randomization or controls and in some cases due to issues with selection bias or inadequate sample size. Reflecting on all available evidence, a staged management algorithm was derived that presents a step-wise approach to implementing the various management and therapeutic options according to disease severity. While this exercise indicated that differentiating between aqueous-deficient and evaporative dry eye disease was critical in selecting the most appropriate management strategy, it also highlighted challenges, based on the limited evidence currently available, in predicting relative benefits of specific management options, in managing the two dry eye disease subtypes. Further evidence is required to support the introduction, and continued use, of many of the treatment options currently available to manage dry eye disease, as well as to inform appropriate treatment starting points and understand treatment specificity in relation to dry eye disease subtype. (C) 2017 Elsevier Inc. All rights reserved.
Keywords Dry eye disease
Dry eye workshop
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Date 2017
Published in Ocular Surface. Amsterdam, v. 15, n. 3, p. 575-628, 2017.
ISSN 1542-0124 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 575-628
Type Article
Web of Science ID WOS:000407081200010

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