Anxiolytic effect of carbamazepine in experimentally-induced anxiety
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Data
1993-02-01
Autores
Sartori, Vânia Aparecida
Andreatini, Roberto
LEITE, José Roberto [UNIFESP]
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The effects of a single oral dose of carbamazepine (CBZ, 200mg), diazepam (DZP, 5mg) or placebo (PLA) were studied in healthy volunteers submitted to the Video-recorded Stroop Color-Word Test (VRSCWT), under double-blind conditions. Twenty-four subjects were randomly assigned to each treatment group (eight in each) and submitted to the State-Trait Anxiety Inventory (STAI) before, during and after the test situation. The results showed that CBZ treatment prevented the increase of state-anxiety scores observed after submitting the subjects to the VRSCWT. Anxiety scores after DZP did not differ from the RA or CBZ group. We concluded that carbamazepine exerts a possible anxiolytic effect in the Stroop-Color Word model of anxiety induction.
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Journal Of Drug Development. Macclesfield: Gardiner-caldwell Communications Ltd, v. 5, n. 4, p. 251-254, 1993.