Anxiolytic effect of carbamazepine in experimentally-induced anxiety

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dc.contributor.authorSartori, Vânia Aparecida
dc.contributor.authorAndreatini, Roberto
dc.contributor.authorLEITE, José Roberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:58:43Z
dc.date.available2018-06-15T17:58:43Z
dc.date.issued1993-02-01
dc.description.abstractThe effects of a single oral dose of carbamazepine (CBZ, 200mg), diazepam (DZP, 5mg) or placebo (PLA) were studied in healthy volunteers submitted to the Video-recorded Stroop Color-Word Test (VRSCWT), under double-blind conditions. Twenty-four subjects were randomly assigned to each treatment group (eight in each) and submitted to the State-Trait Anxiety Inventory (STAI) before, during and after the test situation. The results showed that CBZ treatment prevented the increase of state-anxiety scores observed after submitting the subjects to the VRSCWT. Anxiety scores after DZP did not differ from the RA or CBZ group. We concluded that carbamazepine exerts a possible anxiolytic effect in the Stroop-Color Word model of anxiety induction.en
dc.description.affiliationESCOLA PAULISTA MED SCH,DEPT PSICOBIOL,RUA BOTUCATU,862-1 ANDAR,BR-04023 SAO PAULO,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED SCH,DEPT PSICOBIOL,RUA BOTUCATU,862-1 ANDAR,BR-04023 SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent251-254
dc.identifier.citationJournal Of Drug Development. Macclesfield: Gardiner-caldwell Communications Ltd, v. 5, n. 4, p. 251-254, 1993.
dc.identifier.issn0952-9500
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44346
dc.identifier.wosWOS:A1993KW23200007
dc.language.isoeng
dc.publisherGardiner-caldwell Communications Ltd
dc.relation.ispartofJournal Of Drug Development
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCARBAMAZEPINEen
dc.subjectANXIETYen
dc.subjectDIAZEPAMen
dc.titleAnxiolytic effect of carbamazepine in experimentally-induced anxietyen
dc.typeinfo:eu-repo/semantics/article
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