Metastasis from Oral Cancer: An Overview
Data
2012-09-01
Autores
Noguti, Juliana 
Moura, Carolina Foot Gomes de
Jesus, Gustavo Protasio Pacheco de
Silva, Victor Hugo Pereira da
Hossaka, Thais Ayako
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Oral cancer is a common neoplasm worldwide. Its incidence and mortality have also increased over the past decades. It is characterized by poor prognosis and a low survival rate despite sophisticated surgical and radiotherapeutic modalities. Metastasis of oral cancer is a complex process involving detachment of cells from tumor tissue, regulation of cell motility and invasion, proliferation and evasion through the lymphatic system or blood vessels. In this review, we will focus on the current knowledge in metastasis from oral cancer regarding facts, such as incidence; stage, histopathology and grade of primary tumor; clinical manifestations; diagnosis; and treatment. Certainly, such information will contribute to the understanding of oral cancer pathogenesis.
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Cancer Genomics & Proteomics. Athens: Int Inst Anticancer Research, v. 9, n. 5, p. 329-335, 2012.