SEQUENCING OF HEPARAN-SULFATE PROTEOGLYCANS - IDENTIFICATION OF VARIABLE AND CONSTANT OLIGOSACCHARIDE REGIONS IN 8 HEPARAN-SULFATE PROTEOGLYCANS OF DIFFERENT ORIGINS
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Date
1994-09-01
Authors
Tersariol, Ivarne Luis dos Santos [UNIFESP]
Ferreira, Thais Maria Paiva da Costa [UNIFESP]
Medeiros, Maria das Gracas Liberato de [UNIFESP]
Porcionatto, Marimélia Aparecida [UNIFESP]
Moraes, Carlos Torres [UNIFESP]
Abreu, Luiz Roberto Diz de [UNIFESP]
Nader, Helena Bonciani [UNIFESP]
Dietrich, Carl Peter [UNIFESP]
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Abstract
The sequence of the disaccharide units of eight heparan sulfate proteoglycans of different origins is described. All heparan sulfates contain 5 variable regions made of oligosaccharide blocks of disaccharides, namely, GlcUA(1-4)GlcNAc, GlcUA(1-4)GlcNS, IdoUA (1-4) GlcNS,6S, IdoUA-GlcNAc,6S, and IdoUA,2S(1-4)GlcNS,6S, besides two constant regions made of an internal tetrasaccharide (IdoUA-GlcNAc-IdoUA-GlcNS) and monosaccharides (GlcNS, and GlcNS,6S) at the non-reducing terminal. The N-acetylated region of the heparan sulfates is linked to the serine of the protein core through a trisaccharide of Xyl-Gal-Gal. Heparan sulfates differ from one another in terms of the number of disaccharides that compose each block.
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Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 27, n. 9, p. 2097-2102, 1994.