SEQUENCING OF HEPARAN-SULFATE PROTEOGLYCANS - IDENTIFICATION OF VARIABLE AND CONSTANT OLIGOSACCHARIDE REGIONS IN 8 HEPARAN-SULFATE PROTEOGLYCANS OF DIFFERENT ORIGINS

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dc.contributor.authorTersariol, Ivarne Luis dos Santos [UNIFESP]
dc.contributor.authorFerreira, Thais Maria Paiva da Costa [UNIFESP]
dc.contributor.authorMedeiros, Maria das Gracas Liberato de [UNIFESP]
dc.contributor.authorPorcionatto, Marimélia Aparecida [UNIFESP]
dc.contributor.authorMoraes, Carlos Torres [UNIFESP]
dc.contributor.authorAbreu, Luiz Roberto Diz de [UNIFESP]
dc.contributor.authorNader, Helena Bonciani [UNIFESP]
dc.contributor.authorDietrich, Carl Peter [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T14:28:09Z
dc.date.available2018-06-15T14:28:09Z
dc.date.issued1994-09-01
dc.description.abstractThe sequence of the disaccharide units of eight heparan sulfate proteoglycans of different origins is described. All heparan sulfates contain 5 variable regions made of oligosaccharide blocks of disaccharides, namely, GlcUA(1-4)GlcNAc, GlcUA(1-4)GlcNS, IdoUA (1-4) GlcNS,6S, IdoUA-GlcNAc,6S, and IdoUA,2S(1-4)GlcNS,6S, besides two constant regions made of an internal tetrasaccharide (IdoUA-GlcNAc-IdoUA-GlcNS) and monosaccharides (GlcNS, and GlcNS,6S) at the non-reducing terminal. The N-acetylated region of the heparan sulfates is linked to the serine of the protein core through a trisaccharide of Xyl-Gal-Gal. Heparan sulfates differ from one another in terms of the number of disaccharides that compose each block.en
dc.description.affiliationESCOLA PAULISTA MED,DEPT BIOQUIM,BR-04023970 SAO PAULO,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT BIOQUIM,BR-04023970 SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent2097-2102
dc.identifier.citationBrazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 27, n. 9, p. 2097-2102, 1994.
dc.identifier.issn0100-879X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43073
dc.identifier.wosWOS:A1994PG03900002
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHEPARAN SULFATE, STRUCTUREen
dc.subjectHEPARAN SULFATE, OLIGOSACCHARIDE BLOCKSen
dc.subjectHEPARAN SULFATE, SEQUENCING OF DISACCHARIDESen
dc.titleSEQUENCING OF HEPARAN-SULFATE PROTEOGLYCANS - IDENTIFICATION OF VARIABLE AND CONSTANT OLIGOSACCHARIDE REGIONS IN 8 HEPARAN-SULFATE PROTEOGLYCANS OF DIFFERENT ORIGINSen
dc.typeinfo:eu-repo/semantics/article
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