SEQUENCING OF HEPARAN-SULFATE PROTEOGLYCANS - IDENTIFICATION OF VARIABLE AND CONSTANT OLIGOSACCHARIDE REGIONS IN 8 HEPARAN-SULFATE PROTEOGLYCANS OF DIFFERENT ORIGINS
dc.contributor.author | Tersariol, Ivarne Luis dos Santos [UNIFESP] | |
dc.contributor.author | Ferreira, Thais Maria Paiva da Costa [UNIFESP] | |
dc.contributor.author | Medeiros, Maria das Gracas Liberato de [UNIFESP] | |
dc.contributor.author | Porcionatto, Marimélia Aparecida [UNIFESP] | |
dc.contributor.author | Moraes, Carlos Torres [UNIFESP] | |
dc.contributor.author | Abreu, Luiz Roberto Diz de [UNIFESP] | |
dc.contributor.author | Nader, Helena Bonciani [UNIFESP] | |
dc.contributor.author | Dietrich, Carl Peter [UNIFESP] | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.date.accessioned | 2018-06-15T14:28:09Z | |
dc.date.available | 2018-06-15T14:28:09Z | |
dc.date.issued | 1994-09-01 | |
dc.description.abstract | The sequence of the disaccharide units of eight heparan sulfate proteoglycans of different origins is described. All heparan sulfates contain 5 variable regions made of oligosaccharide blocks of disaccharides, namely, GlcUA(1-4)GlcNAc, GlcUA(1-4)GlcNS, IdoUA (1-4) GlcNS,6S, IdoUA-GlcNAc,6S, and IdoUA,2S(1-4)GlcNS,6S, besides two constant regions made of an internal tetrasaccharide (IdoUA-GlcNAc-IdoUA-GlcNS) and monosaccharides (GlcNS, and GlcNS,6S) at the non-reducing terminal. The N-acetylated region of the heparan sulfates is linked to the serine of the protein core through a trisaccharide of Xyl-Gal-Gal. Heparan sulfates differ from one another in terms of the number of disaccharides that compose each block. | en |
dc.description.affiliation | ESCOLA PAULISTA MED,DEPT BIOQUIM,BR-04023970 SAO PAULO,BRAZIL | |
dc.description.affiliationUnifesp | ESCOLA PAULISTA MED,DEPT BIOQUIM,BR-04023970 SAO PAULO,BRAZIL | |
dc.description.source | Web of Science | |
dc.format.extent | 2097-2102 | |
dc.identifier.citation | Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 27, n. 9, p. 2097-2102, 1994. | |
dc.identifier.issn | 0100-879X | |
dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/43073 | |
dc.identifier.wos | WOS:A1994PG03900002 | |
dc.language.iso | eng | |
dc.publisher | Assoc Bras Divulg Cientifica | |
dc.relation.ispartof | Brazilian Journal Of Medical And Biological Research | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | HEPARAN SULFATE, STRUCTURE | en |
dc.subject | HEPARAN SULFATE, OLIGOSACCHARIDE BLOCKS | en |
dc.subject | HEPARAN SULFATE, SEQUENCING OF DISACCHARIDES | en |
dc.title | SEQUENCING OF HEPARAN-SULFATE PROTEOGLYCANS - IDENTIFICATION OF VARIABLE AND CONSTANT OLIGOSACCHARIDE REGIONS IN 8 HEPARAN-SULFATE PROTEOGLYCANS OF DIFFERENT ORIGINS | en |
dc.type | info:eu-repo/semantics/article |