Persistent hyperactivity of the parathyroid glands in treated hypothyroid patients
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Data
1990-12-01
Autores
Furlanetto, Reinaldo Perrone [UNIFESP]
Lazaretti-Castro, Marise [UNIFESP]
Kasamatsu, Teresa Sayoko [UNIFESP]
Brandao, Cynthia Maria Alvares [UNIFESP]
Vieira, Jose Gilberto Henriques [UNIFESP]
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Twelve untreated hypothyroid patients were submitted to EDTA infusion and the parathyroid hormone response to the induced hypocalcemia was studied with an amino-terminal specific assay. Eight of these patients were retested 6 months after achieving clinical and laboratory euthyroidism. The PTH response in the pretreatment condition was significantly higher than that obtained in a group of 10 normal individuals; this increased response had not normalized after 6 months of euthyroidism. This persisting hyperresponsiveness can be a contributory factor to the bone hypersensitivity to thyroid hormone replacement seen in hypothyroid patients.
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Acta Endocrinologica. Oslo: Scandinavian University Press, v. 123, n. 6, p. 609-612, 1990.