Clinical and molecular epidemiology of neonatal leukemia in Brazil

Clinical and molecular epidemiology of neonatal leukemia in Brazil

Author Moura, Suellen Valadares Google Scholar
Andrade, Francianne Google Scholar
Magalhaes, Isis Q. Google Scholar
Costa, Imarui Google Scholar
Silva, Denise Bousfield Google Scholar
D'Andrea, Maria Lydia Google Scholar
Pinheiro, Vitoria P. Google Scholar
Lee, Maria Lucia M. Google Scholar
Werneck, Fernando Google Scholar
Emerenciano, Mariana Google Scholar
Pombo-de-Oliveira, Maria S. Google Scholar
Institution Inst Nacl Canc
Hosp Crianca Brasilia Jose Alencar
Hosp Infantil Joana Gusmao
Hosp Infantil Darcy Vargas
Ctr Infantil Dr Domingos A Boldrini
Universidade Federal de São Paulo (UNIFESP)
Hosp Fed Servidores Estado
Abstract The clinical and molecular findings of 77 cases of neonatal leukemia (NL) and 380 of infant leukemia (IL) were selected to distinguish features between NL and IL. Somatic gene mutations associated with acute leukemia including FLT3, RAS and PTPN11 were revisited. There were 42 cases of congenital leukemia associated with Down syndrome (DS) and 39 of these cases presented features of acute myeloid leukemia (AML)-M7. Twenty-seven of the DS cases underwent spontaneous remission and were reclassified as a transient myeloproliferative disorder. GATA1 mutations were found in 70% of these cases. in non-DS, frequent abnormalities were MLL rearrangements, mainly MLL-AFF1 in acute lymphoblastic leukemia and MLL-MLLT3 in AML. the FLT3 mutation was not found, while RAS (n = 4) and PTPN11 (n =2) mutations were identified and reported for the first time in NL. There was substantial evidence to support that somatic abnormalities occur in utero. Thus, congenital leukemia is a good model for understanding leukemogenesis.
Keywords Congenital acute lymphoblastic leukemia
acute myeloid leukemia
FLT3
KNRAS
PTPN11
MLL
GATA1
Language English
Date 2015-04-01
Published in Leukemia & Lymphoma. London: Informa Healthcare, v. 56, n. 4, p. 903-909, 2015.
ISSN 1042-8194 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 903-909
Origin http://dx.doi.org/10.3109/10428194.2014.938327
Access rights Closed access
Type Article
Web of Science ID WOS:000353612700014
URI http://repositorio.unifesp.br/handle/11600/38986

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