Clinical and molecular epidemiology of neonatal leukemia in Brazil

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dc.contributor.authorMoura, Suellen Valadares
dc.contributor.authorAndrade, Francianne
dc.contributor.authorMagalhaes, Isis Q.
dc.contributor.authorCosta, Imarui
dc.contributor.authorSilva, Denise Bousfield
dc.contributor.authorD'Andrea, Maria Lydia
dc.contributor.authorPinheiro, Vitoria P.
dc.contributor.authorLee, Maria Lucia M.
dc.contributor.authorWerneck, Fernando
dc.contributor.authorEmerenciano, Mariana
dc.contributor.authorPombo-de-Oliveira, Maria S.
dc.contributor.institutionInst Nacl Canc
dc.contributor.institutionHosp Crianca Brasilia Jose Alencar
dc.contributor.institutionHosp Infantil Joana Gusmao
dc.contributor.institutionHosp Infantil Darcy Vargas
dc.contributor.institutionCtr Infantil Dr Domingos A Boldrini
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Fed Servidores Estado
dc.date.accessioned2016-01-24T14:40:22Z
dc.date.available2016-01-24T14:40:22Z
dc.date.issued2015-04-01
dc.description.abstractThe clinical and molecular findings of 77 cases of neonatal leukemia (NL) and 380 of infant leukemia (IL) were selected to distinguish features between NL and IL. Somatic gene mutations associated with acute leukemia including FLT3, RAS and PTPN11 were revisited. There were 42 cases of congenital leukemia associated with Down syndrome (DS) and 39 of these cases presented features of acute myeloid leukemia (AML)-M7. Twenty-seven of the DS cases underwent spontaneous remission and were reclassified as a transient myeloproliferative disorder. GATA1 mutations were found in 70% of these cases. in non-DS, frequent abnormalities were MLL rearrangements, mainly MLL-AFF1 in acute lymphoblastic leukemia and MLL-MLLT3 in AML. the FLT3 mutation was not found, while RAS (n = 4) and PTPN11 (n =2) mutations were identified and reported for the first time in NL. There was substantial evidence to support that somatic abnormalities occur in utero. Thus, congenital leukemia is a good model for understanding leukemogenesis.en
dc.description.affiliationInst Nacl Canc, Res Ctr, Pediatr Hematol Oncol Program, Rio de Janeiro, Brazil
dc.description.affiliationHosp Crianca Brasilia Jose Alencar, Brasilia, DF, Brazil
dc.description.affiliationHosp Infantil Joana Gusmao, Florianopolis, SC, Brazil
dc.description.affiliationHosp Infantil Darcy Vargas, São Paulo, Brazil
dc.description.affiliationCtr Infantil Dr Domingos A Boldrini, Campinas, SP, Brazil
dc.description.affiliationGRAAC, IOP, Inst Oncol Pediat, São Paulo, Brazil
dc.description.affiliationHosp Fed Servidores Estado, HSE, Rio de Janeiro, Brazil
dc.description.sourceWeb of Science
dc.format.extent903-909
dc.identifierhttp://dx.doi.org/10.3109/10428194.2014.938327
dc.identifier.citationLeukemia & Lymphoma. London: Informa Healthcare, v. 56, n. 4, p. 903-909, 2015.
dc.identifier.doi10.3109/10428194.2014.938327
dc.identifier.issn1042-8194
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38986
dc.identifier.wosWOS:000353612700014
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofLeukemia & Lymphoma
dc.rightsAcesso restrito
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectCongenital acute lymphoblastic leukemiaen
dc.subjectacute myeloid leukemiaen
dc.subjectFLT3en
dc.subjectKNRASen
dc.subjectPTPN11en
dc.subjectMLLen
dc.subjectGATA1en
dc.titleClinical and molecular epidemiology of neonatal leukemia in Brazilen
dc.typeArtigo
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