A sulfated polysaccharide, fucans, isolated from brown algae Sargassum vulgare with anticoagulant, antithrombotic, antioxidant and anti-inflammatory effects
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Date
2013-01-02
Authors
Dore, Celina Maria Pinto Guerra
Alves, Monique Gabriela das Chagas Faustino
Will, Luiza Sheyla Evenni Pofirio
Costa, Thiago Gomes
Sabry, Diego de Araujo [UNIFESP]
Souza, Leonardo Augusto Rêgo de
Accardo, Camila de Melo [UNIFESP]
Rocha, Hugo Alexandre de Oliveira
Filgueira, Luciana Guimarães Alves
Leite, Edda Lisboa
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Abstract
Fucan (SV1) sulfated polysaccharides from the brown algae Sargassum vulgare were extracted, fractionated in acetone and examined with respect to chemical composition, anticoagulant, anti-inflammatory, antithrombotic effects and cellular proliferation. These polysaccharides contain low levels of protein, high level of carbohydrate and sulfate. Monosaccharides analysis revealed that SV1 was composed of fucose, galactose, xylose, glucuronic acid and mannose. SV1 polysaccharide prolonged activated partial thromboplastin time (aPTT) and exhibited high antithrombotic action in vivo, with a concentration ten times higher than heparin activity. PSV1, a purified form in gel filtration showed very low biological activities. SV1 stimulated the enzymatic activity of FXa. Its action on DPPH radical scavenging activity was 22%. This polymer has no cytotoxic action (hemolytic) on ABO and Rh blood types in different erythrocyte groups. It displays strong anti-inflammatory action at all concentrations tested in the carrageenan-induced paw edema model, demonstrated by reduced edema and cellular infiltration. (C) 2012 Elsevier B.V. All rights reserved.
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Carbohydrate Polymers. Oxford: Elsevier B.V., v. 91, n. 1, p. 467-475, 2013.