A sulfated polysaccharide, fucans, isolated from brown algae Sargassum vulgare with anticoagulant, antithrombotic, antioxidant and anti-inflammatory effects

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dc.contributor.authorDore, Celina Maria Pinto Guerra
dc.contributor.authorAlves, Monique Gabriela das Chagas Faustino
dc.contributor.authorWill, Luiza Sheyla Evenni Pofirio
dc.contributor.authorCosta, Thiago Gomes
dc.contributor.authorSabry, Diego de Araujo [UNIFESP]
dc.contributor.authorSouza, Leonardo Augusto Rêgo de
dc.contributor.authorAccardo, Camila de Melo [UNIFESP]
dc.contributor.authorRocha, Hugo Alexandre de Oliveira
dc.contributor.authorFilgueira, Luciana Guimarães Alves
dc.contributor.authorLeite, Edda Lisboa
dc.contributor.institutionUniv Fed Rio Grande do Norte
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:08Z
dc.date.available2016-01-24T14:31:08Z
dc.date.issued2013-01-02
dc.description.abstractFucan (SV1) sulfated polysaccharides from the brown algae Sargassum vulgare were extracted, fractionated in acetone and examined with respect to chemical composition, anticoagulant, anti-inflammatory, antithrombotic effects and cellular proliferation. These polysaccharides contain low levels of protein, high level of carbohydrate and sulfate. Monosaccharides analysis revealed that SV1 was composed of fucose, galactose, xylose, glucuronic acid and mannose. SV1 polysaccharide prolonged activated partial thromboplastin time (aPTT) and exhibited high antithrombotic action in vivo, with a concentration ten times higher than heparin activity. PSV1, a purified form in gel filtration showed very low biological activities. SV1 stimulated the enzymatic activity of FXa. Its action on DPPH radical scavenging activity was 22%. This polymer has no cytotoxic action (hemolytic) on ABO and Rh blood types in different erythrocyte groups. It displays strong anti-inflammatory action at all concentrations tested in the carrageenan-induced paw edema model, demonstrated by reduced edema and cellular infiltration. (C) 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Rio Grande do Norte, Dept Biochem, Lab Glycobiol, BR-59072970 Natal, RN, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biochem, UNIFESP, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biochem, UNIFESP, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipMCT
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent467-475
dc.identifierhttps://dx.doi.org/10.1016/j.carbpol.2012.07.075
dc.identifier.citationCarbohydrate Polymers. Oxford: Elsevier B.V., v. 91, n. 1, p. 467-475, 2013.
dc.identifier.doi10.1016/j.carbpol.2012.07.075
dc.identifier.issn0144-8617
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/35871
dc.identifier.wosWOS:000310253800060
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCarbohydrate Polymers
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectMarine algaeen
dc.subjectFucansen
dc.subjectAnticoagulanten
dc.subjectAntioxidanten
dc.subjectAnti-inflamatoryen
dc.subjectSargassum vulgareen
dc.titleA sulfated polysaccharide, fucans, isolated from brown algae Sargassum vulgare with anticoagulant, antithrombotic, antioxidant and anti-inflammatory effectsen
dc.typeArtigo
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