Effectiveness of probiotics in the prophylaxis of necrotizing enterocolitis in preterm neonates: a systematic review and meta-analysis

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dc.contributor.author Bernardo, Wanderley Marques
dc.contributor.author Aires, Felipe Toyama
dc.contributor.author Carneiro, Renata Mota
dc.contributor.author Sá, Fernando Pereira de
dc.contributor.author Rullo, Vera Esteves Vagnozzi [UNIFESP]
dc.contributor.author Burns, Dennis Alexander
dc.date.accessioned 2016-01-24T14:28:11Z
dc.date.available 2016-01-24T14:28:11Z
dc.date.issued 2013-01-01
dc.identifier http://dx.doi.org/10.1016/j.jped.2013.02.004
dc.identifier.citation Jornal de Pediatria. Rio de Janeiro, Rj: Soc Brasil Pediatria, v. 89, n. 1, p. 18-24, 2013.
dc.identifier.issn 0021-7557
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35650
dc.description.abstract Objective: To elucidate the benefits of using probiotics in the prevention of necrotizing enterocolitis (NEC) and its complications in preterm newborns.Method: This was a systematic review of randomized controlled trials, which included studies retrieved from three databases (MEDLINE, Embase, and LILACS), using a combination of the terms (necrotizing enterocolitis) and (probiotics).Results: 11 randomized trials were included, totaling 2,887 patients, 1,431 in the probiotic group and 1,456 in the control group. There was a reduction in the incidence of NEC (NNT = 25), overall death (NNT = 34), and neonatal sepsis (NNT = 34) in the probiotic group compared to the control group. Patients that received probiotic supplementation had lower food reintroduction time (p < 0.001) and hospitalization time (p < 0.001) when compared to those not receiving probiotics. There was no difference in mortality caused by NEC.Conclusion: in premature newborns, the use of probiotics is effective as a prophylaxis for NEC and its complications. (C) 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved. en
dc.format.extent 18-24
dc.language.iso eng
dc.publisher Soc Brasil Pediatria
dc.relation.ispartof Jornal de Pediatria
dc.rights Acesso aberto
dc.subject Necrotizing enterocolitis en
dc.subject Probiotics en
dc.subject Premature en
dc.title Effectiveness of probiotics in the prophylaxis of necrotizing enterocolitis in preterm neonates: a systematic review and meta-analysis en
dc.type Resenha
dc.contributor.institution Assoc Med Brasileira
dc.contributor.institution Conselho Fed Med
dc.contributor.institution Fac Ciencias Med Santos UNILUS
dc.contributor.institution UNILUS
dc.contributor.institution Soc Brasileira Pediat
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Soc Pediat Dist Fed
dc.description.affiliation Assoc Med Brasileira, Santos, SP, Brazil
dc.description.affiliation Conselho Fed Med, Santos, SP, Brazil
dc.description.affiliation Fac Ciencias Med Santos UNILUS, Santos, SP, Brazil
dc.description.affiliation UNILUS, Santos, SP, Brazil
dc.description.affiliation Soc Brasileira Pediat, Santos, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo UNIFESP, Santos, SP, Brazil
dc.description.affiliation Soc Brasileira Pediat, Brasilia, DF, Brazil
dc.description.affiliation Soc Pediat Dist Fed, Brasilia, DF, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo UNIFESP, Santos, SP, Brazil
dc.identifier.file S0021-75572013000100004.pdf
dc.identifier.scielo S0021-75572013000100004
dc.identifier.doi 10.1016/j.jped.2013.02.004
dc.description.source Web of Science
dc.identifier.wos WOS:000316163600004



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