Effectiveness of probiotics in the prophylaxis of necrotizing enterocolitis in preterm neonates: a systematic review and meta-analysis

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dc.contributor.authorBernardo, Wanderley Marques
dc.contributor.authorAires, Felipe Toyama
dc.contributor.authorCarneiro, Renata Mota
dc.contributor.authorSá, Fernando Pereira de
dc.contributor.authorRullo, Vera Esteves Vagnozzi [UNIFESP]
dc.contributor.authorBurns, Dennis Alexander
dc.contributor.institutionAssoc Med Brasileira
dc.contributor.institutionConselho Fed Med
dc.contributor.institutionFac Ciencias Med Santos UNILUS
dc.contributor.institutionUNILUS
dc.contributor.institutionSoc Brasileira Pediat
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSoc Pediat Dist Fed
dc.date.accessioned2016-01-24T14:28:11Z
dc.date.available2016-01-24T14:28:11Z
dc.date.issued2013-01-01
dc.description.abstractObjective: To elucidate the benefits of using probiotics in the prevention of necrotizing enterocolitis (NEC) and its complications in preterm newborns.Method: This was a systematic review of randomized controlled trials, which included studies retrieved from three databases (MEDLINE, Embase, and LILACS), using a combination of the terms (necrotizing enterocolitis) and (probiotics).Results: 11 randomized trials were included, totaling 2,887 patients, 1,431 in the probiotic group and 1,456 in the control group. There was a reduction in the incidence of NEC (NNT = 25), overall death (NNT = 34), and neonatal sepsis (NNT = 34) in the probiotic group compared to the control group. Patients that received probiotic supplementation had lower food reintroduction time (p < 0.001) and hospitalization time (p < 0.001) when compared to those not receiving probiotics. There was no difference in mortality caused by NEC.Conclusion: in premature newborns, the use of probiotics is effective as a prophylaxis for NEC and its complications. (C) 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.en
dc.description.affiliationAssoc Med Brasileira, Santos, SP, Brazil
dc.description.affiliationConselho Fed Med, Santos, SP, Brazil
dc.description.affiliationFac Ciencias Med Santos UNILUS, Santos, SP, Brazil
dc.description.affiliationUNILUS, Santos, SP, Brazil
dc.description.affiliationSoc Brasileira Pediat, Santos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Santos, SP, Brazil
dc.description.affiliationSoc Brasileira Pediat, Brasilia, DF, Brazil
dc.description.affiliationSoc Pediat Dist Fed, Brasilia, DF, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, ISS, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent18-24
dc.identifierhttp://dx.doi.org/10.1016/j.jped.2013.02.004
dc.identifier.citationJornal de Pediatria. Rio de Janeiro, Rj: Soc Brasil Pediatria, v. 89, n. 1, p. 18-24, 2013.
dc.identifier.doi10.1016/j.jped.2013.02.004
dc.identifier.fileS0021-75572013000100004.pdf
dc.identifier.issn0021-7557
dc.identifier.scieloS0021-75572013000100004
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35650
dc.identifier.wosWOS:000316163600004
dc.language.isoeng
dc.publisherSoc Brasil Pediatria
dc.relation.ispartofJornal de Pediatria
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNecrotizing enterocolitisen
dc.subjectProbioticsen
dc.subjectPrematureen
dc.titleEffectiveness of probiotics in the prophylaxis of necrotizing enterocolitis in preterm neonates: a systematic review and meta-analysisen
dc.typeinfo:eu-repo/semantics/article
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