Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy

Almeida, Sandro Soares [UNIFESP]; Naffah-Mazzacoratti, Maria da Graca [UNIFESP]; Guimarães, Paola Bianchi [UNIFESP]; Wasinski, Frederick [UNIFESP]; Pereira, Flavia Enira Gomes [UNIFESP]; Canzian, Mauro [UNIFESP]; Centeno, Ricardo Silva [UNIFESP]; Carrete Junior, Henrique [UNIFESP]; Yacubian, Elza Márcia Targas [UNIFESP]; Carmona, Adriana Karaoglanovic [UNIFESP]; Vieira, Renata de Freitas Fischer [UNIFESP]; Nakaie, Clovis Ryuichi [UNIFESP]; Sabatini, Regiane Angelica [UNIFESP]; Perosa, Sandra Regina [UNIFESP]; Bacurau, Reury Frank Pereira; Gouveia, Telma Luciana Furtado [UNIFESP]; Gallo, Gloria [UNIFESP]; Wuertele, Martin [UNIFESP]; Cavalheiro, Esper Abrão [UNIFESP]; Silva Junior, Jose Antonio [UNIFESP]; Pesquero, João Bosco [UNIFESP]; Araujo, Ronaldo de Carvalho [UNIFESP]

Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy

Arquivos

WOS000315990800009.pdf(340.54 KB)

Data

2012-03-01

Autores

Almeida, Sandro Soares

Naffah-Mazzacoratti, Maria da Graca

Guimarães, Paola Bianchi

Wasinski, Frederick

Pereira, Flavia Enira Gomes

Mostrar mais

Tipo

Artigo

Resumo

We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin-angiotensin and kallikrein-kinin systems. Translational Psychiatry (2012) 2, e93; doi:10.1038/tp.2012.21; published online 13 March 2012

Citação

Translational Psychiatry. New York: Nature Publishing Group, v. 2, 5 p., 2012.