Nosocomial Bloodstream Infections in Brazilian Hospitals: Analysis of 2,563 Cases from a Prospective Nationwide Surveillance Study
Nenhuma Miniatura disponível
Arquivos
Data
2011-05-01
Autores
Marra, Alexandre Rodrigues [UNIFESP]
Camargo, Luis Fernando Aranha [UNIFESP]
Pignatari, Antonio Carlos Campos [UNIFESP]
Sukiennik, Teresa Cristina Teixeira
Behar, Paulo Renato Petersen
Medeiros, Eduardo Alexandrino Servolo de [UNIFESP]
Ribeiro, Julival
Girao, Evelyne
Correa, Luci
Guerra, Carla Morales
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Nosocomial bloodstream infections (nBSIs) are an important cause of morbidity and mortality. Data from a nationwide, concurrent surveillance study, Brazilian SCOPE (Surveillance and Control of Pathogens of Epidemiological Importance), were used to examine the epidemiology and microbiology of nBSIs at 16 Brazilian hospitals. in our study 2,563 patients with nBSIs were included from 12 June 2007 to 31 March 2010. Ninety-five percent of BSIs were monomicrobial. Gram-negative organisms caused 58.5% of these BSIs, Gram-positive organisms caused 35.4%, and fungi caused 6.1%. the most common pathogens (monomicrobial) were Staphylococcus aureus (14.0%), coagulase-negative staphylococci (CoNS) (12.6%), Klebsiella spp. (12.0%), and Acinetobacter spp. (11.4%). the crude mortality was 40.0%. Forty-nine percent of nBSIs occurred in the intensive-care unit (ICU). the most frequent underlying conditions were malignancy, in 622 patients (24.3%). Among the potential factors predisposing patients to BSI, central venous catheters were the most frequent (70.3%). Methicillin resistance was detected in 157 S. aureus isolates (43.7%). of the Klebsiella sp. isolates, 54.9% were resistant to third-generation cephalosporins. of the Acinetobacter spp. and Pseudomonas aeruginosa isolates, 55.9% and 36.8%, respectively, were resistant to imipenem. in our multicenter study, we found high crude mortality and a high proportion of nBSIs due to antibiotic-resistant organisms.
Descrição
Citação
Journal of Clinical Microbiology. Washington: Amer Soc Microbiology, v. 49, n. 5, p. 1866-1871, 2011.