Amnestic effect of cocaine after the termination of its stimulant action
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Data
2010-02-01
Autores
Niigaki, S. T. [UNIFESP]
Silva, R. H.
Patti, C. L. [UNIFESP]
Cunha, J. L. S. [UNIFESP]
Kameda, S. R. [UNIFESP]
Correia-Pinto, J. C. [UNIFESP]
Takatsu-Coleman, A. L. [UNIFESP]
Levin, R. [UNIFESP]
Abilio, V. C. [UNIFESP]
Frussa-Filho, R. [UNIFESP]
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The effects of cocaine on memory are controversial. Furthermore, the psychostimulant action of cocaine can be a critical issue in the interpretation of its effects on learning/memory models. the effects of a single administration of cocaine on memory were investigated during the presence of its motor stimulating effect or just after its termination. the plus-maze discriminative avoidance task (PM-DAT) was used because it provides simultaneous information about memory, anxiety and motor activity. in Experiment I, mice received saline, 7.5, 10, 15 or 30 mg/kg cocaine 5 min before the training session. in Experiment II, mice were trained 30 min after the injection of saline, 7.5, 10, 15 or 30 mg/kg cocaine. in Experiment III, mice received 30 mg/kg cocaine 30 min pre-training and pre-test. in Experiment IV, mice received 30 mg/kg cocaine immediately post-training. Tests were always conduced 24 h following the training session. Given 5 min before training, cocaine promoted a motor stimulant effect at the highest dose during the training session but did not impair memory. When cocaine was injected 30 min pre-training, the drug did not modify motor activity, but produced marked amnestic effects at all doses tested. This amnesia induced by cocaine given 30 min pre-training was not related to a state-dependent learning because it was not abolished by pretest administration of the drug. Post-training cocaine administration did not induce memory deficits either. Our results suggest that the post-stimulant phase is the critical moment for cocaine-induced memory deficit in a discriminative task in mice. (C) 2009 Published by Elsevier Inc.
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Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 34, n. 1, p. 212-218, 2010.