Amnestic effect of cocaine after the termination of its stimulant action

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dc.contributor.authorNiigaki, S. T. [UNIFESP]
dc.contributor.authorSilva, R. H.
dc.contributor.authorPatti, C. L. [UNIFESP]
dc.contributor.authorCunha, J. L. S. [UNIFESP]
dc.contributor.authorKameda, S. R. [UNIFESP]
dc.contributor.authorCorreia-Pinto, J. C. [UNIFESP]
dc.contributor.authorTakatsu-Coleman, A. L. [UNIFESP]
dc.contributor.authorLevin, R. [UNIFESP]
dc.contributor.authorAbilio, V. C. [UNIFESP]
dc.contributor.authorFrussa-Filho, R. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Rio Grande do Norte
dc.date.accessioned2016-01-24T13:59:16Z
dc.date.available2016-01-24T13:59:16Z
dc.date.issued2010-02-01
dc.description.abstractThe effects of cocaine on memory are controversial. Furthermore, the psychostimulant action of cocaine can be a critical issue in the interpretation of its effects on learning/memory models. the effects of a single administration of cocaine on memory were investigated during the presence of its motor stimulating effect or just after its termination. the plus-maze discriminative avoidance task (PM-DAT) was used because it provides simultaneous information about memory, anxiety and motor activity. in Experiment I, mice received saline, 7.5, 10, 15 or 30 mg/kg cocaine 5 min before the training session. in Experiment II, mice were trained 30 min after the injection of saline, 7.5, 10, 15 or 30 mg/kg cocaine. in Experiment III, mice received 30 mg/kg cocaine 30 min pre-training and pre-test. in Experiment IV, mice received 30 mg/kg cocaine immediately post-training. Tests were always conduced 24 h following the training session. Given 5 min before training, cocaine promoted a motor stimulant effect at the highest dose during the training session but did not impair memory. When cocaine was injected 30 min pre-training, the drug did not modify motor activity, but produced marked amnestic effects at all doses tested. This amnesia induced by cocaine given 30 min pre-training was not related to a state-dependent learning because it was not abolished by pretest administration of the drug. Post-training cocaine administration did not induce memory deficits either. Our results suggest that the post-stimulant phase is the critical moment for cocaine-induced memory deficit in a discriminative task in mice. (C) 2009 Published by Elsevier Inc.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Dept Physiol, BR-59078900 Natal, RN, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundo de Auxilio ao Docente e Aluno da UNIFESP (FADA)
dc.description.sponsorshipAssociacao Fundo de Pesquisa em Psicobiologia (AFIP)
dc.description.sponsorshipAssociacao Fundo de Incentivo Psicofarmacologia (AFIP)
dc.format.extent212-218
dc.identifierhttp://dx.doi.org/10.1016/j.pnpbp.2009.11.010
dc.identifier.citationProgress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 34, n. 1, p. 212-218, 2010.
dc.identifier.doi10.1016/j.pnpbp.2009.11.010
dc.identifier.issn0278-5846
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32230
dc.identifier.wosWOS:000274563400036
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofProgress in Neuro-psychopharmacology & Biological Psychiatry
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCocaineen
dc.subjectMemoryen
dc.subjectPsychostimulant effecten
dc.titleAmnestic effect of cocaine after the termination of its stimulant actionen
dc.typeResenha
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