Hemiparkinsonian rats rotate toward the side with the weaker dopaminergic neurotransmission

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dc.contributor.author Da Cunha, Claudio
dc.contributor.author Wietzikoski, Evellyn Claudia
dc.contributor.author Ferro, Marcelo Machado
dc.contributor.author Martinez, Glaucia Regina
dc.contributor.author Barbato Frazao Vital, Maria Aparecida
dc.contributor.author Hipolide, Debora [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Canteras, Newton Sabino
dc.date.accessioned 2016-01-24T13:51:28Z
dc.date.available 2016-01-24T13:51:28Z
dc.date.issued 2008-06-03
dc.identifier http://dx.doi.org/10.1016/j.bbr.2008.01.012
dc.identifier.citation Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 189, n. 2, p. 364-372, 2008.
dc.identifier.issn 0166-4328
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/30726
dc.description.abstract Rats with unilateral lesion of the substantia nigra pars compacta (SNpc) have been used as a model of Parkinson's disease. Depending on the lesion protocol and on the drug challenge, these rats rotate in opposite directions. the aim of the present study was to propose a model to explain how critical factors determine the direction of these turns. Unilateral lesion of the SNpc was induced with 6-hydroxydopamine (6-OHDA) or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Separate analysis showed that neither the type of neurotoxin nor the site of lesion along the nigrostriatal. pathway was able to predict the direction of the turns these rats made after they were challenged with apomorphine. However, the combination of these two factors determined the magnitude of the lesion estimated by tyrosine-hydroxylase immunohistochemistry and HPLC-ED measurement of striatal dopamine. Very small lesions did Dot cause turns, medium-size lesions caused ipsiversive turns, and large lesions caused contraversive turns. Large-size SNpc lesions resulted in an increased binding of [H-3] raclopride to D2 receptors, while medium-size lesions reduced the binding of [H-3]SCH-23390 D1 receptors in the ipsilateral striatum. These results are coherent with the model proposing that after challenged with a dopamine receptor agonist, unilaterally SNpc-lesioned rats rotate toward the side with the weaker activation of dopamine receptors. This activation is weaker on the lesioned side in animals with small SNpc lesions due to the loss of dopamine, but stronger in animals with large lesions due to dopamine receptor supersensitivity. (C) 2008 Elsevier B.V. All rights reserved. en
dc.format.extent 364-372
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Behavioural Brain Research
dc.rights Acesso restrito
dc.subject substantia nigra pars compacta en
dc.subject turning behaviour en
dc.subject dopamine en
dc.subject basal ganglia en
dc.subject dopamine receptor en
dc.subject Parkinson's disease en
dc.subject MPTP en
dc.subject 6-hydroxydopamine en
dc.title Hemiparkinsonian rats rotate toward the side with the weaker dopaminergic neurotransmission en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal do Paraná (UFPR)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation UFPR, Lab Fisiol & Farmacol Sistema Nervoso Cent, Dept Farmacol, BR-81531980 Curitiba, Parana, Brazil
dc.description.affiliation UFPR, Dept Bioquim & Biol Mol, BR-81531980 Curitiba, Parana, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Dept Anat, Inst Ciencias Biomed 3, BR-09500900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.identifier.doi 10.1016/j.bbr.2008.01.012
dc.description.source Web of Science
dc.identifier.wos WOS:000255604300016


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