Hemiparkinsonian rats rotate toward the side with the weaker dopaminergic neurotransmission

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dc.contributor.authorDa Cunha, Claudio
dc.contributor.authorWietzikoski, Evellyn Claudia
dc.contributor.authorFerro, Marcelo Machado
dc.contributor.authorMartinez, Glaucia Regina
dc.contributor.authorBarbato Frazao Vital, Maria Aparecida
dc.contributor.authorHipolide, Debora [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorCanteras, Newton Sabino
dc.contributor.institutionUniversidade Federal do Paraná (UFPR)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:51:28Z
dc.date.available2016-01-24T13:51:28Z
dc.date.issued2008-06-03
dc.description.abstractRats with unilateral lesion of the substantia nigra pars compacta (SNpc) have been used as a model of Parkinson's disease. Depending on the lesion protocol and on the drug challenge, these rats rotate in opposite directions. the aim of the present study was to propose a model to explain how critical factors determine the direction of these turns. Unilateral lesion of the SNpc was induced with 6-hydroxydopamine (6-OHDA) or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Separate analysis showed that neither the type of neurotoxin nor the site of lesion along the nigrostriatal. pathway was able to predict the direction of the turns these rats made after they were challenged with apomorphine. However, the combination of these two factors determined the magnitude of the lesion estimated by tyrosine-hydroxylase immunohistochemistry and HPLC-ED measurement of striatal dopamine. Very small lesions did Dot cause turns, medium-size lesions caused ipsiversive turns, and large lesions caused contraversive turns. Large-size SNpc lesions resulted in an increased binding of [H-3] raclopride to D2 receptors, while medium-size lesions reduced the binding of [H-3]SCH-23390 D1 receptors in the ipsilateral striatum. These results are coherent with the model proposing that after challenged with a dopamine receptor agonist, unilaterally SNpc-lesioned rats rotate toward the side with the weaker activation of dopamine receptors. This activation is weaker on the lesioned side in animals with small SNpc lesions due to the loss of dopamine, but stronger in animals with large lesions due to dopamine receptor supersensitivity. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationUFPR, Lab Fisiol & Farmacol Sistema Nervoso Cent, Dept Farmacol, BR-81531980 Curitiba, Parana, Brazil
dc.description.affiliationUFPR, Dept Bioquim & Biol Mol, BR-81531980 Curitiba, Parana, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Anat, Inst Ciencias Biomed 3, BR-09500900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent364-372
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2008.01.012
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 189, n. 2, p. 364-372, 2008.
dc.identifier.doi10.1016/j.bbr.2008.01.012
dc.identifier.issn0166-4328
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30726
dc.identifier.wosWOS:000255604300016
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectsubstantia nigra pars compactaen
dc.subjectturning behaviouren
dc.subjectdopamineen
dc.subjectbasal gangliaen
dc.subjectdopamine receptoren
dc.subjectParkinson's diseaseen
dc.subjectMPTPen
dc.subject6-hydroxydopamineen
dc.titleHemiparkinsonian rats rotate toward the side with the weaker dopaminergic neurotransmissionen
dc.typeArtigo
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