Changes in the pro-inflammatory cytokine production and peritoneal macrophage function in rats with chronic heart failure

Changes in the pro-inflammatory cytokine production and peritoneal macrophage function in rats with chronic heart failure

Author Batista, M. L. Google Scholar
Santos, Ronaldo Vagner Thomatieli dos Autor UNIFESP Google Scholar
Cunha, L. M. Google Scholar
Mattos, K. Google Scholar
Oliveira, E. M. Google Scholar
Seelaender, M. C. L. Google Scholar
Rosa, L. F. B. P. Costa Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Chronic heart failure (CHF) is a state of immune activation, and pro-inflammatory cytokines play an important role in its development and progression. Macrophages (M phi s), when activated, are the main source of pro-inflammatory cytokines. We measured interjeukin-6 (IL-6), interleukin (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) production after lipopolysaccharide (LPS)-stimulation, as well as peritoneal M phi s migration, phagocytic capacity, chemotaxis index, and hydrogen peroxide production, in an attempt to clarify the role of this cell in an animal model of CHF. Ligature of the left coronary artery or sham operation was performed in adult Wistar rats. After 12 weeks, resident and total cell number, phagocytic capacity, chemotaxis index, and hydrogen peroxide production in M phi s were significantly higher in CHF than in control rats. the production of IL-6 and TNF-alpha was similarly significantly enhanced in CHF as compared with controls. M phi s obtained from CHF rats were more responsive to LPS, suggesting the existence, in vivo, of possible factor(s) modulating the production of pro-inflammatory cytokines. the results demonstrated that there is modification of peritoneal M phi s function along CHF development, possibly contributing to the pathophysiological process in the establishment of CHF. (c) 2006 Elsevier B.V. All rights reserved.
Keywords Chronic heart failure
Peritoneal macrophages
Chemotaxis
Hydrogen peroxide
Pro-inflammatory cytokines
Language English
Date 2006-06-01
Published in Cytokine. London: Academic Press Ltd Elsevier B.V., v. 34, n. 5-6, p. 284-290, 2006.
ISSN 1043-4666 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 284-290
Origin https://dx.doi.org/10.1016/j.cyto.2006.06.004
Access rights Closed access
Type Article
Web of Science ID WOS:000240536700007
URI https://repositorio.unifesp.br/handle/11600/28947

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