Chronic myeloid leukemia following kidney transplantation
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Data
2005-03-01
Autores
Pelloso, LAF
Campos, MGV de
Nascimento, M.
Silva, MRR
Pestana, JOM
Chauffaille, MDLF
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Artigo
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Immunosuppressed renal recipients are at an increased risk of developing cancer. Leukemias are less frequent than other hematopoietic tumours and development of CML after immunosuppression is rare. We describe a 37-year-old male who presented with left-shifted leukocytosis, hypercellular bone marrow 32 months after the kidney transplant. G-banding karyotype revealed 46,XY,t(9;22)(q34;q11) and the diagnosis of chronic myeloid leukemia was made. This is the 13th case of CML after kidney transplant reported. Whether this CML appeared as a random phenomenon or chemically induced is a matter of debate. Some individuals might have an increased susceptibility to the effects of azathioprine. (C) 2004 Elsevier B.V. All rights reserved.
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Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 29, n. 3, p. 353-355, 2005.