The effect of long-term intermittent trimethoprim/sulfamethoxazole treatment on recurrences of toxoplasmic retinochoroiditis
Nenhuma Miniatura disponível
Data
2002-07-01
Autores
Silveira, C.
Belfort, R.
Muccioli, C.
Holland, G. N.
Victora, C. G.
Horta, B. L.
Nussenblatt, R. B.
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
PURPOSE: To determine the effect of long term intern mittent trimethoprim/sulfamethoxazole treatment on re currences of toxoplasmic retinochoroiditis.DESIGN: Prospective randomized open-labeled inter, ventional clinical trial.METHODS: A total of 124 patients with a history of recurrent toxoplasmic retinochoroiditis were randomized to treatment with one tablet of trimethoprim (160 mg)/ sulfamethoxazole (800 mg) (Bactrim F; Roche Pharmaceuticals, Ric de Janeiro, Brazil) every 3 days (61 patients) or to observation without treatment (63 patients) and were followed monthly for up to 20 consecutive months for clinical signs of disease recurrence. A recurrence was defined as a new focus of necrotizing retinochoroiditis with active inflammation either adjacent to or remote from preexisting retinochoroidal scars.RESULTS: Recurrences developed in four (6.6%) treated patients and in 15 (23.8%) controls (P = .01). Treatment was discontinued prematurely in four patients because of mild drug reactions.CONCLUSION: Long-term intermittent treatment with trimethoprim/sulfamethoxazole can reduce the rate of recurrent toxoplasmic retinochoroiditis. (C) 2002 by Elsevier Science Inc. All rights reserved.
Descrição
Citação
American Journal of Ophthalmology. New York: Elsevier B.V., v. 134, n. 1, p. 41-46, 2002.