The effect of long-term intermittent trimethoprim/sulfamethoxazole treatment on recurrences of toxoplasmic retinochoroiditis

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dc.contributor.authorSilveira, C.
dc.contributor.authorBelfort, R.
dc.contributor.authorMuccioli, C.
dc.contributor.authorHolland, G. N.
dc.contributor.authorVictora, C. G.
dc.contributor.authorHorta, B. L.
dc.contributor.authorNussenblatt, R. B.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionClin Silveira
dc.contributor.institutionUniv Calif Los Angeles
dc.contributor.institutionFed Univ Pelotas
dc.contributor.institutionCatholic Fed Univ
dc.contributor.institutionNEI
dc.date.accessioned2016-01-24T12:33:26Z
dc.date.available2016-01-24T12:33:26Z
dc.date.issued2002-07-01
dc.description.abstractPURPOSE: To determine the effect of long term intern mittent trimethoprim/sulfamethoxazole treatment on re currences of toxoplasmic retinochoroiditis.DESIGN: Prospective randomized open-labeled inter, ventional clinical trial.METHODS: A total of 124 patients with a history of recurrent toxoplasmic retinochoroiditis were randomized to treatment with one tablet of trimethoprim (160 mg)/ sulfamethoxazole (800 mg) (Bactrim F; Roche Pharmaceuticals, Ric de Janeiro, Brazil) every 3 days (61 patients) or to observation without treatment (63 patients) and were followed monthly for up to 20 consecutive months for clinical signs of disease recurrence. A recurrence was defined as a new focus of necrotizing retinochoroiditis with active inflammation either adjacent to or remote from preexisting retinochoroidal scars.RESULTS: Recurrences developed in four (6.6%) treated patients and in 15 (23.8%) controls (P = .01). Treatment was discontinued prematurely in four patients because of mild drug reactions.CONCLUSION: Long-term intermittent treatment with trimethoprim/sulfamethoxazole can reduce the rate of recurrent toxoplasmic retinochoroiditis. (C) 2002 by Elsevier Science Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationClin Silveira, Rio Grande Do Sul, Brazil
dc.description.affiliationUniv Calif Los Angeles, Sch Med, Dept Ophthalmol, Los Angeles, CA 90024 USA
dc.description.affiliationUniv Calif Los Angeles, Sch Med, Jules Stein Eye Inst, Ocular Inflammatory Dis Ctr, Los Angeles, CA 90024 USA
dc.description.affiliationFed Univ Pelotas, Pelotas, Brazil
dc.description.affiliationCatholic Fed Univ, Pelotas, Brazil
dc.description.affiliationNEI, NIH, Bethesda, MD 20892 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent41-46
dc.identifierhttp://dx.doi.org/10.1016/S0002-9394(02)01527-1
dc.identifier.citationAmerican Journal of Ophthalmology. New York: Elsevier B.V., v. 134, n. 1, p. 41-46, 2002.
dc.identifier.doi10.1016/S0002-9394(02)01527-1
dc.identifier.issn0002-9394
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26908
dc.identifier.wosWOS:000176614600006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAmerican Journal of Ophthalmology
dc.rightsAcesso restrito
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.titleThe effect of long-term intermittent trimethoprim/sulfamethoxazole treatment on recurrences of toxoplasmic retinochoroiditisen
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