Age-associated mosaicism and polyploidy in Down's syndrome
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Data
1998-01-12
Autores
Borsatto, B.
Arruda, M. de
Smith, C.
Garcez, EMDM
Peres, C. A.
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Age-related increases in the frequencies of cells with chromosome 21 loss and of polyploid cells were documented in short-term peripheral blood lymphocyte cultures from 54 patients with Down's syndrome (DS), ages 0 to 48 years. the polyploid data, together with previous work from this laboratory with non-DS subjects, suggest that this may be a useful indicator of aging in lymphocytes. (C) 1998 Elsevier Science Ireland Ltd.
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Mechanisms of Ageing and Development. Clare: Elsevier Sci Ireland Ltd, v. 100, n. 1, p. 77-83, 1998.