Age-associated mosaicism and polyploidy in Down's syndrome

Age-associated mosaicism and polyploidy in Down's syndrome

Autor Borsatto, B. Google Scholar
Arruda, M. de Google Scholar
Smith, C. Google Scholar
Garcez, EMDM Google Scholar
Peres, C. A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Age-related increases in the frequencies of cells with chromosome 21 loss and of polyploid cells were documented in short-term peripheral blood lymphocyte cultures from 54 patients with Down's syndrome (DS), ages 0 to 48 years. the polyploid data, together with previous work from this laboratory with non-DS subjects, suggest that this may be a useful indicator of aging in lymphocytes. (C) 1998 Elsevier Science Ireland Ltd.
Palavra-chave Down's syndrome
chromosome 21
aging
polyploidy
Poisson regression
Idioma Inglês
Data de publicação 1998-01-12
Publicado em Mechanisms of Ageing and Development. Clare: Elsevier Sci Ireland Ltd, v. 100, n. 1, p. 77-83, 1998.
ISSN 0047-6374 (Sherpa/Romeo, fator de impacto)
Publicador Elsevier B.V.
Extensão 77-83
Fonte http://dx.doi.org/10.1016/S0047-6374(97)00122-X
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000072099300008
Endereço permanente http://repositorio.unifesp.br/handle/11600/25855

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