Análise cromossômica direta do adenocarcinoma gástrico
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Data
2001
Autores
Assumpção, Paulo Pimentel de [UNIFESP]
Orientadores
Herani Filho, Benedito [UNIFESP]
Tipo
Dissertação de mestrado
Título da Revista
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Resumo
Apresenta-se a análise cromossômica direta do adenocarcinoma gástrico. O câncer de estômago situa-se entre as principais causas de mortalidade por neoplasias, no mundo. No entanto, importantes eventos genéticos relacionados à sua patogênese permanecem indefinidos. Objetiva-se identificar possíveis alterações cromossômicas implicadas na gênese desta neoplasia, avaliando amostras de adenocarcinomas gástricos pelo método de Análise Cromossômica Direta, o qual em função de analisar as amostras imediatamente após sua retirada do tumor primário, minimiza possíveis interferências do período de cultura sobre a análise cromossômica. Estudam-se amostras de dez casos de adenocarcinoma gástricos de pacientes do sexo masculino, no Estado do Pará. Todas as lesões correspondem a estágios avançados de doença segundo a Union Internationale Contre le Câncer – UICC. Observa-se a trissomia do cromossomo 8 na totalidade dos casos correspondendo ao achado mais significativo do estudo, desconhecendo-se ocorrência semelhante na literatura publicada Esta aberração pode corresponder a uma característica regional desta neoplasia ou a um subgrupo citogenético de adenocarcinoma gástrico e torna necessária a realização de estudos complementares objetivando sua confirmação, além da eventual identificação de genes específicos neste cromossomo, implicados na gênese do adenocarcinoma gástrico.
This paper aims at showing the direct chromosomal analyses of the gastric adenocarcinoma. The stomach cancer is placed among the most important causes of neoplasic mortality in the world. However, important events related to its pathogenesis remain unclear. Our purpose is to identify possible chromosomic aberrations brought by the genesis of this neoplasm, evaluating samples of gastric adenocarcinoma by the method of the direct chromosomal analyses, which, due to the fact that it analyses the samples immediately after obtaining them from the primary tumor, reduces the effects of possible interferences of the nurturing period upon the chromosomic analyses. We study samples of ten cases of gastric adenocarcinoma in male patients, in the state of Pará. All lesions were classified as advanced stages according to the Union Internationale Contre le Cancer – ICC. The trisomy of chromosome 8 was observed in all cases, and it was the main finding of this study. We don’t know of any similar event in the literature published up to now. This aberration may be a regional characteristic of that neoplasm or a cytogenetic subgroup of the gastric adenocarcinoma, and makes it necessary to perform additional investigations in order to confirm it, as well as identifying specific genes in this chromosome, related to the genesis of the gastric adenocarcinoma.
This paper aims at showing the direct chromosomal analyses of the gastric adenocarcinoma. The stomach cancer is placed among the most important causes of neoplasic mortality in the world. However, important events related to its pathogenesis remain unclear. Our purpose is to identify possible chromosomic aberrations brought by the genesis of this neoplasm, evaluating samples of gastric adenocarcinoma by the method of the direct chromosomal analyses, which, due to the fact that it analyses the samples immediately after obtaining them from the primary tumor, reduces the effects of possible interferences of the nurturing period upon the chromosomic analyses. We study samples of ten cases of gastric adenocarcinoma in male patients, in the state of Pará. All lesions were classified as advanced stages according to the Union Internationale Contre le Cancer – ICC. The trisomy of chromosome 8 was observed in all cases, and it was the main finding of this study. We don’t know of any similar event in the literature published up to now. This aberration may be a regional characteristic of that neoplasm or a cytogenetic subgroup of the gastric adenocarcinoma, and makes it necessary to perform additional investigations in order to confirm it, as well as identifying specific genes in this chromosome, related to the genesis of the gastric adenocarcinoma.
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Citação
ASSUMPÇÃO, Paulo Pimentel de. Análise cromossômica direta do adenocarcinoma gástrico. Dissertação (Mestrado em Ciências) - Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, 2001.