Navegando por Palavras-chave "reflex epilepsy"

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    Estudo da excitabilidade cortical em pacientes com epilepsia mioclônica juvenil com e sem indução por praxia
    (Universidade Federal de São Paulo (UNIFESP), 2013-11-27) Dourado, Marcos Vidal Pires [UNIFESP]; Manzano, Gilberto Mastrocola Manzano [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    INTRODUCTION: The motor patterns of physiological tactile manipulation of objects and voluntary hand movements, defined as praxis, occur through pathways originated from the premotor cortex, primary motor cortex, parietal cortex and subcortical areas, such as the rubrospinal tract (KANDEL et al., 2000). The cognitive processing of motor behavior can induce epileptiform discharges and/or epileptic seizures in a subgroup of patients with Juvenile Myoclonic Epilepsy (JME), (GUARANHA et al., 2009). OBJECTIVE: This project aimed to study the motor and somatosensory cortical excitability in patients with JME, without praxis induction (JME-WI) and with epileptiform discharges and/or seizures induced by praxis (JME-PRX) compared with that of healthy controls. METHOD: The sample (n=36) was composed by JME-WI (n=12), JME-PRX (n=10) and control group (n=14) and was assessed by parameters of bilateral motor cortical excitability, tested by transcranial magnetic stimulation of single pulse: motor threshold, latency of motor evoked potential, central motor conduction time, contralateral and ipsilateral silent period. Bilateral somatosensory excitability was assessed by absolute values and interpeak measures of latencies and amplitudes of cortical components N20, P27, N35 and P45 tested by somatosensory evoked potentials. RESULTS: Analysis of variance (p<0.05) did not show differences with statistical significance for the study of motor excitability parameters assessed in both hemispheres, such as motor threshold [p=0.785 (D); p=0.661 (E)], motor evoked potential [p=0.644 (D); p=0.702 (E)] and central motor conduction time [p=0.776 (D); p=0.904 (E)]. The ipsilateral silent period of the left hemisphere in patients with JME-WI showed the smallest measures, when compared to control group and effect size of d=0.83, r=0.38 demonstrated a high relevance due to strong clinical significance of the coefficients in this parameter. The effect size became more evident when we compare the left hemisphere values between JME-WI group and the JME-PRX group, which presented the greatest measures of ipsilateral silent period and effect size with d=0.95, r=0.43, compared to control group. The analysis of the interpeak latency N35-P45 showed a significant difference for the variance among the three groups (p=0.020), and greatest value for this interpeak latency in patients with JME-PRX comparing with the control group (p=0.007). The analysis of variance of the amplitudes showed a difference in the mean value of the interpeak latency N27-N35 among the three groups (p=0.036), such as in the group with JME-PRX compared to the control group (p=0.013). CONCLUSIONS: The increase in the amplitude and latency of the interpeak intervals suggest greater excitability of the somatosensory cortex in patients with JME and epileptiform discharges and/or seizures induced by praxis. This findings show distinct patterns of cortical excitability between the two groups of patients.
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    Language- and praxis-induced jerks in patients with juvenile myoclonic epilepsy
    (John Libbey Eurotext Ltd, 2005-06-01) Sousa, Patricia da Silva [UNIFESP]; Lin, Katia [UNIFESP]; Garzon, Eliana [UNIFESP]; Sakamoto, Américo Ceiki [UNIFESP]; Yacubian, Elza Márcia Targas [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Reflex traits have been described in patients with idiopathic generalized epilepsy. We report on four patients with juvenile myoclonic epilepsy in whom the coexistence of praxis- and language-induced jerks was documented in video-polygraphic EEG recordings. [Published with video sequences].